Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
RPS6KA2
→
MAPK1
(increases, MAPK1 Activity, RPS6KA2 Activity)
Evidence: several downstream substrates of ERK1/2 kinase have been identified (Brunet & Pouyssegur, 1997), including p90 ribosomal S6 kinase (p90rsk, also known as MAPK-activated protein kinase (MAPKAP-K) 1; Zhao et al. 1996) and mitogen- and stress-activated kinases (MSK) 1 and 2 (Deak et al. 1998).
OpenBEL Selventa BEL large corpus:
RPS6KA2
→
MAPK1
(directlyIncreases, RPS6KA2 Activity)
Pullen et al., Science 1998* Evidence: Etienne-Manneville and Hall (2003) used primary rat astrocytes in a cell migration assay to demonstrate that PAR6-PKC-zeta interacts directly with and regulates glycogen synthase kinase-3-beta (GSK3-beta; 605004) to promote polarization of the centrosome and to control the direction of cell protrusion. CDC42-dependent phosphorylation of GSK3-beta occurs specifically at the leading edge of migrating cells, and induces the interaction of APC (175100) protein with the plus ends of microtubules. Erk...