◀ Back to HDAC3
HDAC3 — PIK3R1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Furuya et al., Mol Cell Biol 2007
(Thyroid Neoplasms) :
Since NCoR is known to modulate the actions of TRbeta mutants in vivo and in vitro, we asked whether
NCoR regulates PV-activated
PI3K signaling ... Overexpression of
NCoR in thyroid tumor cells of TRbetaPV/PV mouse
reduced PI3K signaling, as indicated by the decrease in the phosphorylation of its immediate downstream effector, p-AKT
Furuya et al., Steroids 2009
(Thyroid Neoplasms) :
Conversely, lowering cellular
NCoR by siRNA knockdown in tumor cells
leads to over activated
PI3K-AKT signaling to increase cell proliferation and motility
Alam et al., J Biol Chem 2011
(Inflammation) :
Importantly,
HDAC3 was
essential for the constitutive transcription of
PI3K and IRF3, which might be responsible for the basal level of galectin-9 expression