Kelly et al., J Biol Chem 2005
(Alzheimer Disease...) :
In addition, our results provided evidence that the Abeta induced decrease in dynamin 1 was likely the result of a calpain mediated cleavage of dynamin 1 protein and possibly the down-regulation of dynamin 1 gene expression
Kelly et al., J Biol Chem 2006
(Alzheimer Disease) :
We report here that this dynamin 1 degradation was the result of calpain activation induced by the sustained calcium influx mediated by N-methyl-D-aspartate receptors in hippocampal neurons
Nicholson et al., Mol Med 2012
:
Our results showed that Dutch mutant Aß ( E22Q ) induced calpain mediated cleavage of dynamin 1 and a significant decrease in synaptic contacts in mature hippocampal cultures