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CDKN1A — PRDX2
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Xiao et al., J Cell Biochem 1999
:
To identify the transcription factor which is responsible for histone deacetylase inhibitor induced expression of p21WAF1 and understand the potential events occurred during this process, we analyze the
response of the mouse
p21WAF1 promoter to
TSA in detail ... These findings provide physical and functional evidence which strongly indicated that both Sp1 and Sp3 are responsible for
TSA induced
transactivation of the murine
p21WAF1 promoter in NIH3T3 cells
Gray et al., Exp Cell Res 1999
(Carcinoma, Hepatocellular...) :
The results show that the
induction of
p21 by
TSA can be modulated by additions of IGF-II whereas addition of TGFbeta1 affects its own expression but not p21
Xiao et al., J Biol Chem 2000
:
The evidence supporting the linkage between p300 and
TSA induced
p21 promoter activation were realized from the following findings : 1 ) cotransfection of p300 elevated p21 promoter activity, and this elevation was dependent on TSA-responsive GC-box ; 2 ) TSA induced promoter activation was blocked by the introduction of p300 dominant negative mutant into cells ; and 3 ) Sp1- or Sp3 mediated activation was also suppressed by this p300 dominant negative mutant
Sowa et al., Ann N Y Acad Sci 1999
:
TSA induced growth arrest and expression of the
p21/WAF1/Cip1 protein ... This finding indicates that
TSA activates the
p21/WAF1/Cip1 promoter through the Sp1 sites in a p53 independent manner
Suzuki et al., Int J Cancer 2000
(Mouth Neoplasms...) :
TSA enhanced the protein expression of
p21 ( WAF1 ), CREB binding protein, cyclinE, cyclin A, Bak and Bax, while it reduced the expression of E2F-1, E2F-4, HDAC1, p53 and hyperphosphorylated form of Rb
Sawa et al., Brain Tumor Pathol 2001
(Brain Neoplasms...) :
In this study, we showed that
TSA also
increased p21 expression, suggesting that histone deacetylase (HDAC) inhibitors may up-regulate p21 protein in common and thus arrest proliferation in the G1 phase of the cell cycle
Friedman et al., Cancer Res 2002
(Colonic Neoplasms) :
Induction of the Sp1 regulated
p21 gene by
Trichostatin A (TSA) was blocked by ET-743 at concentrations that had minimal effect on uninduced ( constitutive ) expression
Chen et al., Cancer Lett 2002
(Colonic Neoplasms) :
Cyclohexamide and
TSA super
induced the expression of GADD45alpha and beta, but not
p21 ( cip/waf )
Strait et al., Mol Cancer Ther 2002
(Ovarian Neoplasms) :
In conclusion, the observed
TSA induced changes in
p21 , Rb, and Id1 are consistent with cell cycle senescence and differentiation of A2780 ovarian cancer cells
Blagosklonny et al., Mol Cancer Ther 2002
:
Here we show that the HDIs sodium butyrate ( Bu ),
trichostatin A (TSA) and depsipeptide ( FR901228 ) all
induced p21 , but only TSA and FR901228 caused mitotic arrest ( in addition to arrest in G1 and G2 )
Donadelli et al., Mol Carcinog 2003
(Adenocarcinoma...) :
The expression of
p21 ( WAF1/CIP1 ) normally induced at the transcriptional level by p53 was also strongly
activated by
TSA
Flørenes et al., Melanoma Res 2004
(Melanoma) :
TSA significantly
induced protein expression of the cyclin dependent kinase inhibitor
p21 ( WAF1/CIP1 ) in a dose dependent manner in all cell lines including those not expressing p21 ( WAF1/CIP1 ) constitutively, whereas the levels of both wild-type and mutated p53 protein were reduced
Li et al., Biochem Biophys Res Commun 2004
(Uterine Cervical Neoplasms) :
In this study, we observed that
Trichostatin A (TSA) , a HDAC inhibitor,
induced strikingly
p21WAF1/CIP1 expression in human cervical cancer ( HeLa ) cells, and this induction correlated with downregulation of c-myc expression ... Taken together,
TSA induced c-myc downregulation and release from the endogenous p21WAF1/CIP1 promoter
contributes , at least partially, to transcriptional activation of the
p21WAF1/CIP1 in HeLa cells
Ryu et al., Cancer Lett 2006
(Pancreatic Neoplasms) :
The expressions of
p21 and cyclin D2 were up-regulated and that of cyclin B1 was
down-regulated by
TSA or SK-7041
Jüngel et al., Ann Rheum Dis 2006
(Arthritis, Rheumatoid...) :
Induction of the cell cycle inhibitor
p21Waf/Cip1 by
TSA was analysed by western blot ...
TSA induced cell cycle arrest in RASF through up regulation of
p21Waf1/Cip1
Zhao et al., Mol Cell Biol 2006
:
Here we found that an inhibitor of HDAC, depsipeptide ( FR901228 ), but not
trichostatin A (TSA) ,
induces p21 ( Waf1/Cip1 ) expression through both p53 and Sp1/Sp3 pathways in A549 cells ( which retain wild-type p53 )
Zhang et al., Oncol Rep 2006
(Stomach Neoplasms) :
TSA increases the expression of
p21 , p53, DAPK-1 and the DAPK-2 gene in both OCUM-8 and MKN-74 cells
Okamoto et al., J Atheroscler Thromb 2006
:
TSA treatment also
induced the expression of
p21 ( WAF1 ) but not of p16(INK4), p27 ( KIP1 ) or p53
Svechnikova et al., Biochem Biophys Res Commun 2007
(Carcinoma, Hepatocellular...) :
With the help of anti-sense p21 expression, we show here that
p21 is
mediating the apoptotic effects of HDACi 4-phenylbutyrate ( 4-PB ) and
Trichostatin A (TSA) on the hepatocellular hepatocarcinoma Hep3B cells
Yi et al., Exp Mol Med 2007
(Bone Resorption) :
TSA caused the upregulation of
p21WAF1 in osteoclasts ... Collectively, our results provide evidence that
TSA causes osteoclast apoptosis, which involves, in part, TSA induced upregulation of
p21 ( WAF1 ), and strongly supports HDIs as potential therapeutic agents for excessive bone resorption
Huber et al., Arthritis Rheum 2007
(Disease Models, Animal...) :
Western blot analysis revealed an
up-regulation of the cell cycle inhibitor
p21 by
TSA , leading to reduced proliferation of fibroblasts
Malinen et al., Nucleic Acids Res 2008
(Breast Neoplasms) :
TSA induced the INK4-family genes p18 and p19, whereas the Cip/Kip family gene
p21 was stimulated by 1alpha,25 ( OH ) 2D3
Bajbouj et al., J Neurooncol 2012
(Glioblastoma) :
Immunofluorescence staining revealed that
TSA induced the nuclear translocation of
p21 ( WAF1 ) verifying a cell cycle arrest
Zhao et al., PloS one 2012
(Endometrial Neoplasms) :
p21 and BIM, which were identified as target genes of miR-106b-93-25 cluster,
increased in
TSA treated tumor cells and were responsible for cell cycle arrest and apoptosis
Sachweh et al., Cell death & disease 2013
:
As both Nutlin-3 and
TSA increase the levels of the cell cycle inhibitor
p21 ( cip1/waf1 ) in cells, we investigated whether a combination of these compounds would further augment p21 levels