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BCL2 — CDKN1A

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Kang et al., Exp Cell Res 1999 (Carcinoma, Hepatocellular...) : Overexpression of Bcl-2 not only suppressed apoptosis but also completely prevented induction of p21 and Bax caused by ceramide in SK-Hep-1 cells
Chou et al., Biochem J 2000 (Stomach Neoplasms) : Moreover, the close correlation between the effect of Bcl-2 on both RA-induced growth arrest and RA-induced p21 gene expression suggests the possibility that Bcl-2 affects cell growth through the mechanism of p21
Crescenzi et al., Gynecol Oncol 2001 (Adenocarcinoma...) : Bcl-2 overexpression resulted in a reduced cell proliferation rate, decreased cloning efficiency, appreciable cell morphology changes, G2/M cell cycle arrest, remarkable accumulation of the dephosphorylated form of retinoblastoma protein, and a significant rise in p21 ( WAF1/CIP1 )
Giannakakou et al., Oncogene 2001 : In HCT116 cells, loss of p53 ( HCT/p53 ( -/- ) ) or p21 ( HCT/p21 ( -/- ) ) affects both Bax and Bcl-2 expression
DeHaan et al., Cancer Chemother Pharmacol 2001 : In the ovarian carcinoma cell line A2780, cisplatin was shown to induce expression of p21WAF1, Gadd45 and Mdm2, but cisplatin had no effect on expression of Bax, Bcl-2, Bcl-x1 , or Cyclin G. Inhibition of cisplatin induced ERK activity by PD98059 resulted in decreased levels of p21WAF1 , Gadd45 and Mdm2
Jia et al., Wei Sheng Yan Jiu 2001 (Liver Neoplasms...) : Furthermore, tea polyphenols and tea pigments induced the expression of p21WAF1 protein, inhibited the expression of Bcl-2 protein and induced the expression of Bax protein
Ahmed et al., Cell cycle (Georgetown, Tex.) 2004 (Leukemia) : Unexpectedly, enforced expression of p21 ( Cip1/WAF1 ) diminished paclitaxel mediated inactivation of ERK, and reduced paclitaxel induced activation of JNK as well as Bcl-2 phosphorylation
Akita et al., Virology 2005 : p21WAF1 modulates NF-kappaB signaling and induces anti-apoptotic protein Bcl-2 in Tax expressing rat fibroblast
Su et al., Anticancer Res 2006 : Curcumin also promoted the expression of Bax, cytochrome C, p53 and p21 but inhibited the expression of Bcl-2
Liu et al., Int J Oncol 2009 (Leukemia) : In identifying a molecular mechanism responsible for these effects MCT-1 alone and in combination with AZA induced p15INK4b, p21WAF1/CIP1 and Caspase-3 whilst attenuating Bcl-XL expression
Festuccia et al., Endocr Relat Cancer 2009 (Disease Models, Animal...) : In vivo, azacitidine ( 0.8 mg/kg i.p. ) reduced tumor proliferation and induced apoptosis in both xenografts upmodulating the expression of p16INKA, Bax, Bak, p21/WAF1 , and p27/KIP1, and inhibiting the activation of Akt activity and the expression of cyclin D1, Bcl-2, and Bcl-XL
Gravina et al., Prostate 2010 (Neoplasms, Experimental...) : This combined treatment up-regulated the expression of FasL, phospho-FADD, p16 ( INKA ), Bax, Bak, and p21 ( WAF1 ), and inhibited FLIP, Bcl-2, and Bcl-XL expression ... This combined treatment up-regulated the expression of FasL, phospho-FADD, p16 ( INKA ), Bax, Bak, and p21 ( WAF1 ), and inhibited FLIP, Bcl-2 , and Bcl-XL expression
Sadagopan et al., Oncogene 2012 : In contrast, angiogenin expression blocked pro-apoptotic Bax and p21 expression, induced Bcl-2 and blocked cell death
Liu et al., PloS one 2012 (Stomach Neoplasms) : In addition, the expression level of p21 , p53 and Caspase-9 were increased when AP-4 was knockdown, but the expression of cyclin D1, Bcl-2 and Bcl-x ( L ) was inhibited
Vincent et al., FEBS Lett 2012 (Breast Neoplasms) : Our studies reveal that NUPR1 confers growth benefit and chemoresistance by causing Akt mediated phosphorylation and subsequent cytoplasmic re-localization of p21 and activation of the anti-apoptotic Bcl-xL protein
Miyashita et al., J Biol Chem 1995 (Adrenal Gland Neoplasms...) : The results demonstrate that levels of the proapoptotic p21Bax protein can be post-translationally regulated by Bcl-2 , probably in a tissue-specific fashion, and suggest the existence of a feedback mechanism that may help to maintain the ratio of Bcl-2 to Bax protein in physiologically appropriate ranges
Han et al., Genes Dev 1996 : bax mRNA and protein levels were p53-inducible with kinetics identical to that of p21/Waf-1/Cip-1, and E1B 19K and Bcl-2 expression did not affect Bax or p21/Waf-1/Cip-1 accumulation