◀ Back to CD79A
BLNK — CD79A
Pathways - manually collected, often from reviews:
-
BioCarta bcr signaling pathway:
B-cell antigen/BCR/CD79A/CD79B/Btk/LYN/BLNK complex (BCR-CD79A-CD79B-BTK-LYN-BLNK)
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, activates)
-
BioCarta bcr signaling pathway:
LYN
→
B-cell antigen/BCR/CD79A/CD79B/Btk/LYN/BLNK complex (BCR-CD79A-CD79B-BTK-LYN-BLNK)
(modification, collaborate)
-
BioCarta bcr signaling pathway:
B-cell antigen/BCR/CD79A/CD79B/Btk/LYN/BLNK complex (BCR-CD79A-CD79B-BTK-LYN-BLNK)
→
BLNK
(modification, collaborate)
-
BioCarta bcr signaling pathway:
B-cell antigen/BCR/CD79A/CD79B/Btk/LYN/BLNK complex (BCR-CD79A-CD79B-BTK-LYN-BLNK)
→
BTK
(modification, collaborate)
-
BioCarta bcr signaling pathway:
B-cell antigen/BCR/CD79A/CD79B/Btk/LYN/BLNK complex (BCR-CD79A-CD79B-BTK-LYN-BLNK)
→
B-cell antigen/BCR complex complex (BCR-CD79A-CD79B)
(modification, collaborate)
-
BioCarta bcr signaling pathway:
BLNK
→
B-cell antigen/BCR complex complex (BCR-CD79A-CD79B)
(modification, collaborate)
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK)
→
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
(modification, collaborate)
Adachi et al., J Biol Chem 2001
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK)
→
CD72/SHP1 complex (CD72-PTPN6)
(modification, collaborate)
Adachi et al., J Biol Chem 2001
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK)
→
SHP1 (PTPN6)
(modification, collaborate)
Adachi et al., J Biol Chem 2001
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
→
CD72/SHP1 complex (CD72-PTPN6)
(modification, collaborate)
Adachi et al., J Biol Chem 2001
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
→
SHP1 (PTPN6)
(modification, collaborate)
Adachi et al., J Biol Chem 2001
-
NCI Pathway Database BCR signaling pathway:
SAB (SH3BP5)
→
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
(modification, inhibits)
Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
-
NCI Pathway Database BCR signaling pathway:
SAB (SH3BP5)
→
B-cell antigen/BCR complex/LYN/SYK/BLNK complex (LYN-SYK-BLNK-CD79B-CD79A)
(modification, inhibits)
Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
→
PLCgamma2 (PLCG2)
(modification, collaborate)
Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
→
B-cell antigen/BCR complex/LYN/SYK/BLNK complex (LYN-SYK-BLNK-CD79B-CD79A)
(modification, collaborate)
Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
→
Btk (BTK)
(modification, collaborate)
Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
-
NCI Pathway Database BCR signaling pathway:
PLCgamma2 (PLCG2)
→
B-cell antigen/BCR complex/LYN/SYK/BLNK complex (LYN-SYK-BLNK-CD79B-CD79A)
(modification, collaborate)
Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/LYN/SYK/BLNK complex (LYN-SYK-BLNK-CD79B-CD79A)
→
Btk (BTK)
(modification, collaborate)
Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/LYN/SYK/BLNK complex (LYN-SYK-BLNK-CD79B-CD79A)
→
IBtk (IBTK)
(modification, collaborate)
Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
-
NCI Pathway Database BCR signaling pathway:
BLNK (BLNK)
→
B-cell antigen/BCR complex/LYN/SYK complex (LYN-SYK-CD79B-CD79A)
(modification, collaborate)
Kabak et al., Mol Cell Biol 2002
Evidence: physical interaction
-
NCI Pathway Database BCR signaling pathway:
BLNK (BLNK)
→
B-cell antigen/BCR complex/LYN/SYK/BLNK complex (LYN-SYK-BLNK-CD79B-CD79A)
(modification, collaborate)
Kabak et al., Mol Cell Biol 2002
Evidence: physical interaction
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/LYN/SYK complex (LYN-SYK-CD79B-CD79A)
→
B-cell antigen/BCR complex/LYN/SYK/BLNK complex (LYN-SYK-BLNK-CD79B-CD79A)
(modification, collaborate)
Kabak et al., Mol Cell Biol 2002
Evidence: physical interaction
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK)
→
CD72 (CD72)
(modification, collaborate)
Fusaki et al., Eur J Immunol 2000
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK)
→
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
(modification, collaborate)
Fusaki et al., Eur J Immunol 2000
-
NCI Pathway Database BCR signaling pathway:
CD72 (CD72)
→
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
(modification, collaborate)
Fusaki et al., Eur J Immunol 2000
-
NCI Pathway Database BCR signaling pathway:
CD19 (CD19)
→
B-cell antigen/BCR complex/LYN/SYK/BLNK complex (LYN-SYK-BLNK-CD79B-CD79A)
(modification, activates)
O'Rourke et al., Immunity 1998
Evidence: assay, physical interaction
-
NCI Pathway Database BCR signaling pathway:
SHIP (INPP5D)
→
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
(modification, inhibits)
-
NCI Pathway Database BCR signaling pathway:
None
→
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
(modification, collaborate)
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
(modification, activates)
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
→
None
(modification, activates)
-
Reactome Reaction:
CD79A
→
BLNK
(indirect_complex)
Watanabe et al., Biochem Biophys Res Commun 2000, Engels et al., Eur J Immunol 2001, Kabak et al., Mol Cell Biol 2002, Chiu et al., EMBO J 2002, Oellerich et al., Mol Cell Proteomics 2009, Oellerich et al., EMBO J 2011, Fu et al., J Biol Chem 1997, Fu et al., Immunity 1998, Wienands et al., J Exp Med 1998
-
Reactome Reaction:
CD79A
→
BLNK
(reaction)
Watanabe et al., Biochem Biophys Res Commun 2000, Engels et al., Eur J Immunol 2001, Kabak et al., Mol Cell Biol 2002, Chiu et al., EMBO J 2002, Oellerich et al., Mol Cell Proteomics 2009, Oellerich et al., EMBO J 2011, Fu et al., J Biol Chem 1997, Fu et al., Immunity 1998, Wienands et al., J Exp Med 1998
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
CD79A
—
BLNK
(physical association, affinity chromatography technology)
Oellerich et al., EMBO J 2011
-
IRef Biogrid Interaction:
CD79A
—
BLNK
(physical association, affinity chromatography technology)
Kabak et al., Mol Cell Biol 2002
-
IRef Biogrid Interaction:
CD79A
—
BLNK
(direct interaction, pull down)
Engels et al., Eur J Immunol 2001
-
IRef Biogrid Interaction:
CD79A
—
BLNK
(direct interaction, pull down)
Kabak et al., Mol Cell Biol 2002
-
IRef Hprd Interaction:
BLNK
—
CD79A
(in vitro)
Engels et al., Eur J Immunol 2001, Kabak et al., Mol Cell Biol 2002
-
IRef Hprd Interaction:
BLNK
—
CD79A
(in vivo)
Engels et al., Eur J Immunol 2001, Kabak et al., Mol Cell Biol 2002
-
IRef Ophid Interaction:
CD79A
—
BLNK
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Benschop et al., J Immunol 2001
:
BCR induced tyrosine phosphorylation of CD79a, Lyn,
B cell linker protein , and phospholipase Cgamma2 is enhanced in immature B cells and they exhibit greater capacitative calcium entry in response to Ag
Kövesdi et al., Cell Signal 2002
(Calcium Signaling) :
Both
BLNK and phospholipase C ( PLC ) gamma were raft associated in unstimulated pre-B cells, and this could not be
enhanced by
pre-BCR engagement, suggesting a ligand independent PLC gamma mediated signaling
Tsubata et al., Int Rev Immunol 2001
:
BCR proximal signaling occurs within cholesterol- and sphingolipid-rich plasma membrane microdomains termed lipid rafts, and
involves tyrosine kinases such as Lyn, Syk and Btk and the adapter molecule
SLP65/BLNK
Zhang et al., EMBO J 1998
:
By monitoring the activation of signaling elements in pervanadate stimulated B cells expressing different levels of the BCR, we show here that phosphorylation of
SLP-65 and Syk, but not of Lyn, is strictly
dependent on the expression of the
BCR on the cell surface