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RNF43 — WNT11
Text-mined interactions from Literome
Koo et al., Nature 2012
(Adenoma...) :
We conclude that
RNF43 and ZNRF3
reduce Wnt signals by selectively ubiquitinating frizzled receptors, thereby targeting these Wnt receptors for degradation
Jiang et al., Proc Natl Acad Sci U S A 2013
(Carcinoma, Pancreatic Ductal...) :
Here, we show that
RNF43 inhibits
Wnt/ß-catenin signaling by reducing the membrane level of Frizzled in pancreatic cancer cells, serving as a negative feedback mechanism