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MAP3K14 — TRAF2

Pathways - manually collected, often from reviews:

• BioCarta tnfr2 signaling pathway: TNF-beta/TNF R2/RIP/TRAF1/TRAF2/TRAF3/I-TRAF complex (TANK-TNFRSF1B-TRAF2-TRAF1-LTA-TRAF3-RIPK1) → MAP3K14 (modification, activates)
• BioCarta induction of apoptosis through dr3 and dr4/5 death receptors: DR3/TRADD/FADD/TRAF2/RIP/Caspase 8/Caspase 10/APO-3L complex (TNFRSF25-TRADD-FADD-TRAF2-RIPK1-CASP8-CASP10-TNFSF12) → MAP3K14 (modification, activates)
• KEGG Apoptosis: TRAF2 → MAP3K14 (protein-protein, activation)
• KEGG Osteoclast differentiation: TRAF2/TRAF6 → Complex of CHUK-MAP3K14 (protein-protein, activation)
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) → NIK (MAP3K14) (modification, activates) Malinin et al., Nature 1997
• NCI Pathway Database CD40/CD40L signaling: cIAP1/cIAP2/TRAF2/TRAF3 complex (BIRC2-BIRC3-TRAF2-TRAF3) → NIK (MAP3K14) (modification, activates) Vallabhapurapu et al., Nat Immunol 2008, Zarnegar et al., Nat Immunol 2008
  Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: MAP3K14 — TRAF2 Song et al., Proc Natl Acad Sci U S A 1997*
• IRef Bind_translation Interaction: MAP3K14 — TRAF2 (coimmunoprecipitation) Song et al., Proc Natl Acad Sci U S A 1997*
• IRef Biogrid Interaction: MAP3K14 — TRAF2 (physical association, affinity chromatography technology) Luftig et al., J Biol Chem 2001*
• IRef Biogrid Interaction: MAP3K14 — TRAF2 (direct interaction, pull down) Luftig et al., J Biol Chem 2001*
• IRef Biogrid Interaction: MAP3K14 — TRAF2 (direct interaction, two hybrid) Malinin et al., Nature 1997
• IRef Biogrid Interaction: MAP3K14 — TRAF2 (physical association, affinity chromatography technology) Malinin et al., Nature 1997
• IRef Biogrid Interaction: MAP3K14 — TRAF2 (physical association, affinity chromatography technology) Song et al., Proc Natl Acad Sci U S A 1997*
• IRef Biogrid Interaction: MAP3K14 — TRAF2 (physical association, affinity chromatography technology) Liao et al., J Biol Chem 2004*
• IRef Biogrid Interaction: MAP3K14 — TRAF2 (physical association, affinity chromatography technology) Sanjo et al., J Biol Chem 2010*
• IRef Biogrid Interaction: MAP3K14 — TRAF2 (physical association, affinity chromatography technology) Zheng et al., Mol Cell 2010*
• IRef Biogrid Interaction: MAP3K14 — TRAF2 (physical association, affinity chromatography technology) Kanno et al., J Recept Signal Transduct Res 2010*
• IRef Biogrid Interaction: MAP3K14 — TRAF2 (physical association, affinity chromatography technology) Choudhary et al., J Biol Chem 2013*
• IRef Hprd Interaction: Complex of 26 proteins (in vivo) Zarnegar et al., Nat Immunol 2008
• IRef Hprd Interaction: MAP3K14 — TRAF2 (in vivo) Luftig et al., J Biol Chem 2001*, Liao et al., J Biol Chem 2004*, Vallabhapurapu et al., Nat Immunol 2008, Malinin et al., Nature 1997
• IRef Hprd Interaction: MAP3K14 — TRAF2 (in vitro) Luftig et al., J Biol Chem 2001*, Liao et al., J Biol Chem 2004*, Vallabhapurapu et al., Nat Immunol 2008, Malinin et al., Nature 1997
• IRef Ophid Interaction: MAP3K14 — TRAF2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: MAP3K14 — TRAF2 (aggregation, confirmational text mining) Luftig et al., J Biol Chem 2001*

Text-mined interactions from Literome

Guasparri et al., EMBO Rep 2006 : TRAF2 , but not TRAF3, mediates the association of vFLIP with the IkappaB kinase complex
Pantano et al., Am J Respir Cell Mol Biol 2007 : Furthermore, Nox1 used the TNF-RI adaptor protein TNF-receptor associated factor-2 (TRAF2) , and the redox regulated JNK MAP3K , apoptosis signal kinase-1 (ASK1), to activate JNK