Gene interactions and pathways from curated databases and text-mining

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MAP2K4 — TRAF2

Pathways - manually collected, often from reviews:

  • BioCarta tnfr1 signaling pathway: TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD) → JNKK1 (MAP2K4) (modification, activates)
  • NCI Pathway Database CD40/CD40L signaling: CD40/CD40L (trimer)/TRAF2 (trimer)/MEKK1 complex (CD40LG-CD40-TRAF2-MAP3K1) → MKK4 (MAP2K4) (modification, activates) Gallagher et al., Nat Immunol 2007
    Evidence: assay

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *