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IRAK1 — STAT3
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Huang et al., J Biol Chem 2004
(Arteriosclerosis) :
In this report, we show that
IRAK1 is mainly
involved in
Stat3 activation and subsequent interleukin-10 (IL-10) gene expression ...
IRAK1 can directly use Stat3 as a substrate and
cause Stat3 serine 727 phosphorylation
Ngo et al., Nature 2011
(Burkitt Lymphoma...) :
The L265P mutant promoted cell survival by spontaneously assembling a protein complex containing IRAK1 and IRAK4, leading to IRAK4 kinase activity,
IRAK1 phosphorylation, NF-?B signalling, JAK kinase
activation of
STAT3 , and secretion of IL-6, IL-10 and interferon-ß