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PCNA — SKP2
Text-mined interactions from Literome
Yeh et al., Biochem Biophys Res Commun 2001
:
We report that
SKP2 , an F-box protein and a substrate targeting component of the SCF ( SKP2 ) ubiquitin E3 ligase complex,
mediates cyclin E degradation ... Our findings suggest that
SKP2 regulates
cyclin E stability, thus contributing to the control of S phase progression
Wang et al., Blood 2011
(Leukemia) :
Mechanistically, we show that
Skp2 deficiency
induces Cyclin D1 gene expression, which contributes to an increase in HSC cycling