◀ Back to MYLIP
MDM2 — MYLIP
Text-mined interactions from Literome
Kim et al., J Biol Chem 2010
:
miR-221 was necessary and
sufficient to down-regulate
Mdm2 expression, and this down-modulation of Mdm2 by miR-221 prevented the degradation of ( and consequently up-regulated ) the Slug protein, which negatively regulates the proliferation of chondroprogenitors
Li et al., Blood 2013
(Leukemia, Myeloid, Acute) :
Suppression of miR-193a expands the oncogenic activity of the fusion protein AML-ETO, because
miR-193a represses the expression of multiple target genes, such as AML1/ETO, DNMT3a, HDAC3, KIT, CCND1, and
MDM2 directly, and increases PTEN indirectly
Dar et al., J Natl Cancer Inst 2013
(Melanoma...) :
The
role of
miR-18b in
MDM2-p53 pathway signaling and melanoma progression
Li et al., Oncotarget 2012
(Glioblastoma...) :
Finally, we demonstrated that
miR-17 could
repress MDM2 levels, resulting in decreased cell proliferation and drug-resistance