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LDLR — MYLIP
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Dong et al., Int J Mol Med 2011
:
While the induction of PCSK9 transcription has been recognized as a limitation to the statin cholesterol lowering efficacy at higher doses, it is unknown whether
Idol is
involved in the statin mediated up-regulation of the hepatic
LDLR
Scotti et al., Mol Cell Biol 2011
:
Idol stimulates
LDLR degradation through ubiquitination of its C-terminal domain, thereby limiting cholesterol uptake
Guo et al., Cancer Discov 2011
(Brain Neoplasms...) :
Targeting LDLR with the liver X receptor ( LXR ) agonist GW3965 caused
inducible degrader of LDLR (IDOL) mediated
LDLR degradation and increased expression of the ABCA1 cholesterol efflux transporter, potently promoting tumor cell death in an in vivo GBM model
Qin et al., Zhong Nan Da Xue Xue Bao Yi Xue Ban 2012
:
To investigate the
effect of
miR-590-5p on the expression of lectin-like oxidized
low density lipoprotein receptor 1 ( LOX-1 ) in apoptotic human umbilical vein endothelial cells ( HUVECs ) induced by ox-LDL, and to explore the role of miR-590-5p in modulating HUVECs apoptosis
Sorrentino et al., Eur Heart J 2013
(Hyperlipoproteinemia Type II) :
Briefly,
IDOL promotes degradation of the
LDLR thereby limiting LDL uptake
Scotti et al., Mol Cell Biol 2013
:
Small interfering RNA ( siRNA ) -mediated knockdown of ESCRT-0 ( HGS ) or ESCRT-I ( TSG101 ) components prevents
IDOL mediated
LDLR degradation