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AGO1 — MYLIP
Text-mined interactions from Literome
Bowman et al., Bioessays 2004
:
Three recent papers provide insight into how miRNAs, likely acting through a complex containing an Argonaute protein, regulate Class III HD-Zip gene expression in Arabidopsis and maize.1-3 While the precise biological activity of Argonaute proteins remains an enigma,
ARGONAUTE1 in Arabidopsis is
required for the proper regulation of
miRNA165/166 , which targets cleavage of Class III HD-Zip mRNAs
Gazzani et al., BMC evolutionary biology 2009
:
This complex auto-regulatory loop, composed of miR168 guided AGO1 catalyzed cleavage of AGO1 mRNA and
AGO1 mediated stabilization of
miR168 , was shown to ensure the maintenance of AGO1 homeostasis that is pivotal for the correct functioning of the miRNA pathway
Mallory et al., EMBO Rep 2009
:
We have previously reported that AGO1 homeostasis is maintained through the repressive action of miR168 on
AGO1 mRNA and the stabilizing
effect of AGO1 protein on
miR168 , but siRNA mediated AGO1 regulation has not been reported
Vaucheret et al., PloS one 2009
:
Only the 21-nt miR168 is preferentially stabilized by
AGO1 , and consequently, the accumulation of the 22-nt but not the 21-nt
miR168 is
reduced when DCL1 activity is impaired
Zhang et al., PloS one 2012
:
Transfection assay revealed that both
Ago1 and Ago2 synergistically
induced miR-21 and
miR-21* when the mir-21 plasmid was co-transfected with either