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Yang et al., Prostate 2003
(Prostatic Neoplasms) :
At 50 microg/ml, 12-MTA increased caspase-3 activity four to seven-fold compared with that in control cells
Buqué et al., Molecular cancer 2012
(Melanoma) :
We found that MTA induced DNA damage and mitochondrial mediated apoptosis in human melanoma cells in vitro and that the associated apoptosis was both caspase dependent and -independent and p53 mediated