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MMP7 — PLG
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Ramos-DeSimone et al., J Biol Chem 1999
(Neoplasm Invasiveness) :
When the MMP-9/TIMP ratio exceeds 1.0,
MMP-9 activation progresses, but through an interacting protease cascade
involving plasmin and stromelysin 1 ( MMP-3 )
Balcerzak et al., J Anim Sci 2001
:
The
MMP are
regulated at the levels of transcription, zymogen activation by
plasmin or membrane-type- ( MT ) MMP, and control of enzyme activity by tissue inhibitors of metalloproteinases ( TIMP )
Hosomi et al., Stroke 2001
(Acute Disease...) :
Plasminogen activators (PAs) may also play a role in ECM degradation by the generation of
plasmin or by
MMP activation
Monea et al., J Cell Physiol 2002
:
Thus,
plasmin can activate proMMP-2 only in the
presence of
MT1-MMP ; however, this process does not require the catalytic activity of MT1-MMP
May et al., Thromb Haemost 2005
(Arteriosclerosis) :
We studied the effect of E-LDL on the activation of
plasminogen and matrix metalloproteinases ( MMPs ) in monocytes and vascular smooth muscle cells ( VSMCs ) as well as on
MMP activation during cellular interactions
Tan et al., Int J Oncol 2006
(Adenocarcinoma...) :
On the other hand,
plasmin-treatment induced the expression of matrix metalloproteinase-2 (MMP-2),
MMP-7 and MMP-9 in PC-1 cells
Stempien-Otero et al., J Biol Chem 2006
(Fibrosis) :
We did not detect
plasmin mediated
activation of TGF-beta1,
MMP-2 , or MMP-9 in hearts of SR-uPA+/o mice
Salo et al., Spine (Phila Pa 1976) 2008
(Disease Models, Animal...) :
Profiling of various MMPs and plasmin, known to participate in mutual activation cascades, suggests that
plasmin could
activate pro-MMP-1, pro-MMP-2, pro-MMP-3,
pro-MMP-7 , pro-MMP-9, and pro-MMP-13 and alone or/and in cooperation with MMP-3 initiate at least 2 mutual MMPs activation cascades driven by activated MMP-3 and MMP-7
Park et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2010
:
Plasminogen activator inhibitor (PAI)-1 is known to play an important role in renal ECM accumulation in part through suppression of
plasmin generation and
matrix metalloproteinase ( MMP ) activation
Ghosh et al., J Cell Physiol 2012
(Fibrosis) :
During wound healing, elevated levels of PAI-1 inhibit uPA/tPA/plasmin and
plasmin dependent
MMP activities, and, thus, help expedite wound healing
Patterson et al., J Biol Chem 1997
:
These results indicate that
MMP-7 and MMP-9 may
regulate new blood vessel formation by cleaving
plasminogen and generating angiostatin molecules