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MAPK8 — PLD1
Text-mined interactions from Literome
Min et al., Exp Mol Med 2002
(MAP Kinase Signaling System) :
Interestingly, specific inhibition of p38
MAPK with SB203580
attenuated pervanadate induced
PLD activation
Cummings et al., Mol Cell Biochem 2002
:
In pulmonary epithelial and vascular endothelial cells, a wide variety of agonists stimulate
PLD and
involve Src kinases, p-38
mitogen activated protein kinase , calcium and small G proteins
Grab et al., Biochim Biophys Acta 2004
:
Differential
role for
phospholipase D1 and phospholipase D2 in 12-O-tetradecanoyl-13-phorbol acetate stimulated
MAPK activation, Cox-2 and IL-8 expression
Fernández-Tome et al., Biochem Biophys Res Commun 2004
:
p44/42 ( ERK1/2 )
MAPK and
PLD activation by PGD2 preserves papillary phosphatidylcholine homeostasis
Park et al., J Biol Chem 2009
:
Der f 2-induced
PLD activation was
attenuated by PLCgamma inhibitors ( U73122 and PAO ), PKCalpha inhibitors ( RO320432 and GO6976 ), and p38
MAPK inhibitors ( SB203580 and SB202190 )
Chen et al., Science signaling 2012
(Breast Neoplasms...) :
PLD1 deficiency
suppressed the activation of Akt and
mitogen activated protein kinase signaling pathways by vascular endothelial growth factor in vascular endothelial cells, resulting in decreased integrin dependent cell adhesion to, and migration on, extracellular matrices, as well as reduced tumor angiogenesis in a xenograft model
Ito et al., J Neurochem 1998
:
Possible
involvement of
mitogen activated protein kinase in
phospholipase D activation induced by H2O2, but not by carbachol, in rat pheochromocytoma PC12 cells