◀ Back to MAPK8
MAP3K1 — MAPK8
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
MAPK8
→
MAP3K1
(increases, MAP3K1 Activity, MAPK8 Activity)
Evidence: Grx2 significantly activated the Ras/phosphoinositide 3-kinase/Akt/NF-kappaB cascade in parallel to the Jun N-terminal kinase (JNK)/AP1 cascade.
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OpenBEL Selventa BEL large corpus:
MAPK8
→
MAP3K1
(increases, MAP3K1 Activity, MAPK8 Activity)
Kolluri et al., Mol Cell Biol 2003*
Evidence: When the expression vector for JNK1-DN was cotransfected, the inhibitory effect of MEKK1-DA on TR3-dependent transactivation was largely relieved. In contrast, cotransfection of JNK2-DN or JNK3-DN did not show any effect on MEKK1-DA activity.
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OpenBEL Selventa BEL large corpus:
MAPK8
→
MAP3K1
(increases, MAP3K1 Activity, MAPK8 Activity)
Song et al., Proc Natl Acad Sci U S A 1997*
Evidence: Modified assertion
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KEGG RIG-I-like receptor signaling pathway:
MAP3K1
→
MAPK10/MAPK8/MAPK9
(protein-protein, activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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IRef Biogrid Interaction:
MAP3K1
—
MAPK8
(physical association, affinity chromatography technology)
Ryoo et al., J Biol Chem 2004*
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IRef Biogrid Interaction:
MAP3K1
—
MAPK8
(direct interaction, enzymatic study)
Tu et al., J Biol Chem 2003*
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IRef Biogrid Interaction:
MAP3K1
—
MAPK8
(physical association, affinity chromatography technology)
Gallagher et al., J Biol Chem 2002*
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IRef Biogrid Interaction:
MAP3K1
—
MAPK8
(direct interaction, enzymatic study)
Sun et al., Oncol Rep 2011*
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IRef Biogrid Interaction:
MAP3K1
—
MAPK8
(direct interaction, enzymatic study)
Xu et al., J Biol Chem 1997*
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IRef Biogrid Interaction:
MAP3K1
—
MAPK8
(direct interaction, pull down)
Xu et al., J Biol Chem 1997*
-
IRef Biogrid Interaction:
MAP3K1
—
MAPK8
(physical association, affinity chromatography technology)
Xu et al., J Biol Chem 1997*
Text-mined interactions from Literome
Uhlik et al., Biochem Cell Biol 2004
(MAP Kinase Signaling System) :
Wiring diagrams of
MAPK regulation by
MEKK1 , 2, and 3
Korchnak et al., Cell Signal 2009
:
Mixed lineage kinase 3 (MLK3) is a mitogen activated protein kinase kinase kinase (
MAP3K ) that
activates multiple mitogen activated protein kinase (
MAPK ) pathways in response to growth factors, stresses and the pro-inflammatory cytokine, tumor necrosis factor (TNF)
Xu et al., Proc Natl Acad Sci U S A 1995
:
MEKK1 phosphorylates MEK1 and MEK2 but does not
cause activation of
mitogen activated protein kinase