◀ Back to MAPK8
MAP2K7 — MAPK8
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
MAPK8
→
MAP2K7
(directlyIncreases, MAPK8 Activity)
Fleming et al., Biochem J 2000*
Evidence: Here we report that MKK4 shows a striking preference for the tyrosine residue (Tyr-185), and MKK7 a striking preference for the threonine residue (Thr-183) in three SAPK1/JNK1 isoforms tested (JNK1 alpha 1, JNK2 alpha 2 and JNK3 alpha 1)
-
OpenBEL Selventa BEL large corpus:
MAPK8
→
MAP2K7
(directlyIncreases, MAPK8 Activity)
Evidence: 95141073;15911620;15755722;9312068
-
BioCarta tnf/stress related signaling:
MKK7/MEK4 (MAP2K7/MAP2K4)
→
JNK1 (MAPK8)
(modification, activates)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
MKK7 (MAP2K7)
→
JNK1 (MAPK8)
(modification, activates)
-
BioCarta mapkinase signaling pathway:
MKK7/MEK4 (MAP2K7/MAP2K4)
→
JNK1/MAPK9/MAPK10 (MAPK10/MAPK8/MAPK9)
(modification, activates)
-
BioCarta keratinocyte differentiation:
MKK7 (MAP2K7)
→
JNK1 (MAPK8)
(modification, activates)
-
KEGG Protein processing in endoplasmic reticulum:
MAP2K7
→
MAPK10/MAPK8/MAPK9
(protein-protein, activation)
-
KEGG Osteoclast differentiation:
MAP2K7
→
MAPK10/MAPK8/MAPK9
(protein-protein, activation)
-
KEGG Toll-like receptor signaling pathway:
MAP2K4/MAP2K7
→
MAPK10/MAPK8/MAPK9
(protein-protein, phosphorylation)
-
KEGG Fc epsilon RI signaling pathway:
MAP2K4/MAP2K7
→
MAPK10/MAPK8/MAPK9
(protein-protein, activation)
-
KEGG Neurotrophin signaling pathway:
MAP2K7
→
MAPK10/MAPK8/MAPK9
(protein-protein, activation)
-
KEGG GnRH signaling pathway:
MAP2K4/MAP2K7
→
MAPK10/MAPK8/MAPK9
(protein-protein, activation)
-
KEGG MAPK signaling pathway:
MAP2K7
→
MAPK10/MAPK8/MAPK9
(protein-protein, phosphorylation)
-
KEGG Influenza A:
MAP2K4/MAP2K7
→
MAPK10/MAPK8/MAPK9
(protein-protein, activation)
-
KEGG ErbB signaling pathway:
MAP2K4/MAP2K7
→
MAPK10/MAPK8/MAPK9
(protein-protein, activation)
-
NCI Pathway Database FAS (CD95) signaling pathway:
MKK7 (MAP2K7)
→
JNK family-active (MAPK8/MAPK9/MAPK10)
(modification, activates)
Toyoshima et al., J Cell Biol 1997
Evidence: assay
-
NCI Pathway Database FAS (CD95) signaling pathway:
MKK7 (MAP2K7)
→
JNK family (MAPK8/MAPK9/MAPK10)
(modification, activates)
Toyoshima et al., J Cell Biol 1997
Evidence: assay
-
NCI Pathway Database Reelin signaling pathway:
RELN/LRP8/DAB1/Fyn/MAPK8IP1/MKK7/MAP3K11/JNK1 complex (DAB1-RELN-FYN-LRP8-MAPK8-MAP3K11-MAP2K7-ARHGEF2)
→
MAPK8IP1/MKK7/MAP3K11/JNK1 complex (MAP2K7-MAP3K11-MAPK8-ARHGEF2)
(modification, collaborate)
Stockinger et al., J Biol Chem 2000
Evidence: assay, other species
-
NCI Pathway Database Reelin signaling pathway:
RELN/LRP8/DAB1/Fyn/MAPK8IP1/MKK7/MAP3K11/JNK1 complex (DAB1-RELN-FYN-LRP8-MAPK8-MAP3K11-MAP2K7-ARHGEF2)
→
RELN/LRP8/DAB1/Fyn complex (RELN-LRP8-FYN-DAB1)
(modification, collaborate)
Stockinger et al., J Biol Chem 2000
Evidence: assay, other species
-
NCI Pathway Database Reelin signaling pathway:
MAPK8IP1/MKK7/MAP3K11/JNK1 complex (MAP2K7-MAP3K11-MAPK8-ARHGEF2)
→
RELN/LRP8/DAB1/Fyn complex (RELN-LRP8-FYN-DAB1)
(modification, collaborate)
Stockinger et al., J Biol Chem 2000
Evidence: assay, other species
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
MKK7 (MAP2K7)
→
JNK1 (MAPK8)
(modification, activates)
-
NCI Pathway Database PDGFR-beta signaling pathway:
MKK4-MKK7 (MAP2K7/MAP2K4)
→
JNK family (MAPK8/MAPK9/MAPK10)
(modification, activates)
Chiariello et al., Nat Cell Biol 2001, Zhao et al., J Exp Med 2001, Furstoss et al., EMBO J 2002, Iavarone et al., J Biol Chem 2003, Boureux et al., J Cell Sci 2005
Evidence: mutant phenotype, assay
-
Reactome Reaction:
MAPK8
→
MAP2K7
(reaction)
Sato et al., Nat Immunol 2005, Wang et al., Mol Cell Biol 2007*, Deacon et al., J Biol Chem 1997
-
WikiPathways ErbB Signaling Pathway:
MAP2K7
→
MAPK8
(activation)
-
WikiPathways MicroRNAs in cardiomyocyte hypertrophy:
MAP2K4/MAP2K7
→
MAPK8
(activation)
-
WikiPathways Structural Pathway of Interleukin 1 (IL-1):
MAP2K7
→
MAPK8/MAPK9/MAPK10
(activation)
-
WikiPathways Cardiac Hypertrophic Response:
MAP2K4/MAP2K7
→
MAPK8
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind_translation Interaction:
MAP2K7
—
MAPK8
(experimental interaction detection)
Huang et al., Biochem Biophys Res Commun 2003*
-
IRef Biogrid Interaction:
MAP2K7
—
MAPK8
(direct interaction, enzymatic study)
Ho et al., J Biol Chem 2006
-
IRef Biogrid Interaction:
MAP2K7
—
MAPK8
(direct interaction, unspecified method)
Ho et al., J Biol Chem 2006
-
IRef Biogrid Interaction:
MAP2K7
—
MAPK8
(direct interaction, enzymatic study)
Enomoto et al., Biochem Biophys Res Commun 2003*
-
IRef Biogrid Interaction:
MAP2K7
—
MAPK8
(direct interaction, enzymatic study)
Tournier et al., Proc Natl Acad Sci U S A 1997*
-
IRef Biogrid Interaction:
MAP2K7
—
MAPK8
(physical association, affinity chromatography technology)
Cheng et al., Mol Cell Biol 2000*
-
IRef Biogrid Interaction:
MAP2K7
—
MAPK8
(direct interaction, pull down)
Ho et al., J Biol Chem 2006
-
IRef Biogrid Interaction:
MAP2K7
—
MAPK8
(physical association, affinity chromatography technology)
Ho et al., J Biol Chem 2006
-
IRef Hprd Interaction:
Complex of 26 proteins
(in vivo)
Blanco et al., PloS one 2008
-
IRef Hprd Interaction:
Complex of 26 proteins
(in vivo)
Figueroa et al., J Biol Chem 2003
-
IRef Hprd Interaction:
Complex of 37 proteins
(in vivo)
Blanco et al., PloS one 2008
-
IRef Hprd Interaction:
MAP2K7
—
MAPK8
(in vitro)
Fleming et al., Biochem J 2000*, Ho et al., J Biol Chem 2006, Tournier et al., Proc Natl Acad Sci U S A 1997*
-
IRef Hprd Interaction:
MAP2K7
—
MAPK8
(in vivo)
Fleming et al., Biochem J 2000*, Ho et al., J Biol Chem 2006, Tournier et al., Proc Natl Acad Sci U S A 1997*
-
IRef Innatedb Interaction:
MAPK8
—
MAP2K7
(unknown, -)
Enomoto et al., Biochem Biophys Res Commun 2003*
-
IRef Innatedb Interaction:
MAPK8
—
MAP2K7
(unknown, -)
Cheng et al., Mol Cell Biol 2000*
-
IRef Innatedb Interaction:
Complex of MAP2K7-MAP2K4-MAPK8
(unknown, -)
Sundarrajan et al., Arthritis Rheum 2003*
-
IRef Innatedb Interaction:
Complex of MAP2K7-MAP3K2-MAPK8
(unknown, -)
Cheng et al., Mol Cell Biol 2000*
-
IRef Intact Interaction:
Complex of MAP2K7-MAPK8-MAP3K7
(physical association, molecular sieving)
Blanco et al., Mol Cell Biol 2007*
-
IRef Intact Interaction:
Complex of MAPK8-MAP2K7-TAB1-MAP3K7-MAPK8IP1
(association, molecular sieving)
Blanco et al., PloS one 2008
-
IRef Intact Interaction:
Complex of MAPK8-MAP2K7
(association, pull down)
Ho et al., J Biol Chem 2006
-
IRef Intact Interaction:
Complex of VRK2-MAPK8IP1-MAPK8-MAP2K7-TAB1-MAP3K7
(association, molecular sieving)
Blanco et al., PloS one 2008
-
IRef Intact Interaction:
Complex of MAPK8-VRK2-MAP3K7-TAB1-MAPK8IP1-MAP2K7
(association, molecular sieving)
Blanco et al., PloS one 2008
-
IRef Intact Interaction:
MAPK8
—
MAP2K7
(direct interaction, pull down)
Ho et al., J Biol Chem 2006
-
IRef Intact Interaction:
MAPK8
—
MAP2K7
(physical association, anti tag coimmunoprecipitation)
Ho et al., J Biol Chem 2006
-
IRef Intact Interaction:
Complex of MAP2K7-MAP2K4-MAPK8
(association, pull down)
Ho et al., J Biol Chem 2006
-
IRef Ophid Interaction:
MAPK8
—
MAP2K7
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
MAPK8
—
MAP2K7
(aggregation, confirmational text mining)
Tournier et al., Proc Natl Acad Sci U S A 1997*
Text-mined interactions from Literome
Martel-Pelletier et al., Arthritis Rheum 1999
(Osteoarthritis) :
Within minutes, IL-17 induced the phosphorylation of
mitogen activated protein kinase kinase-1/2 ( MEK-1/2 ), -3/6 ( MKK-3/6 ), p44/42, p38, and inhibitor of nuclear factor kappaB ( I kappaB)-alpha, as well as the
activation of
mitogen activated protein kinase activated protein kinase-1 and -2 ( MAPKAPK-1 and -2 )
Tu et al., J Biomed Sci 2001
(Carcinoma, Hepatocellular) :
On the other hand, PD98059, a specific inhibitor of
mitogen activated protein kinase kinase ,
blocks TPA induced
MAPK activation but has no effect on TPA induced tyrosine phosphorylation
Huang et al., Biochem Biophys Res Commun 2003
:
MAP3Ks are components of a three tiered protein kinase pathway in which a MAP3K phosphorylates and activates a
mitogen activated protein kinase kinase ( MAP2K ), which in turn
activates a
mitogen activated protein kinase ( MAPK )
Huwiler et al., Br J Pharmacol 1994
:
2. Both nucleotides stimulate phosphorylation and
activation of
mitogen activated protein kinase and a biphasic phosphorylation of the up-stream
mitogen activated protein kinase kinase
Daum et al., FEBS Lett 1998
:
Pervanadate inhibits
mitogen activated protein kinase kinase-1 in a
p38MAPK dependent manner