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LEP — SOAT1

Text-mined interactions from Literome

Morton et al., J Mol Endocrinol 1999 (Diabetes Mellitus, Type 2...) : Conditions that mimic increased metabolic activity resulted in attenuation of leptin mediated STAT DNA binding but had no significant effect on STAT3 tyrosine phosphorylation in RINm5F cells
Magoffin et al., Ginekol Pol 1999 (Breast Neoplasms) : Leptin causes the activation of STAT proteins within target cells
Briscoe et al., J Mol Endocrinol 2001 (Insulinoma) : A chronic treatment ( 5 days ) of BRIN-BD11 cells with FAs similarly attenuated leptin stimulated STAT tyrosine phosphorylation
Carvalheira et al., Biol Chem 2003 : Interaction between leptin and insulin signaling pathways differentially affects JAK-STAT and PI 3-kinase mediated signaling in rat liver
Ishida-Takahashi et al., J Biol Chem 2004 (MAP Kinase Signaling System) : To clarify the molecular mechanism by which GCs rapidly reduce leptin induced JAK/STAT signaling, we examined the intracellular signal transduction pathway potentially mediated by GCs ... PD98059, a specific MEK inhibitor, blocked the inhibitory effects of GCs on leptin induced JAK/STAT activation in Huh7 cells
Bai et al., J Huazhong Univ Sci Technolog Med Sci 2004 (Atherosclerosis) : Thus, our results support the idea that expression of ACAT-1 increases more in cultured human macrophages than in monocytes, and leptin can significantly promote ACAT-1 expression
Pai et al., Biochem Biophys Res Commun 2005 (Stomach Neoplasms) : While JAK inhibition with AG490 significantly reduced leptin induced ERK2, STAT3 phosphorylation, and cell proliferation, SHP2 inhibition only partially reduced cancer cell proliferation
Laubner et al., Diabetes 2005 (Insulinoma...) : In conclusion, although SOCS3 is believed to be a negative feedback regulator of JAK-STAT signaling, our findings suggest involvement of SOCS3 in a direct gene regulatory pathway downstream of leptin activated JAK-STAT signaling in pancreatic beta-cells
Leung et al., Kidney Int 2006 : The Janus kinase-signal transducers and activation ( JAK-STAT ) signal transduction pathway in mesothelial cells was activated by either exogenous or adipocytes derived leptin
Férézou-Viala et al., Am J Physiol Regul Integr Comp Physiol 2007 (Body Weight...) : To evaluate hypothalamic leptin sensitivity in each group, STAT-3 phosphorylation was measured in response to leptin or saline intraperitoneal bolus
Miyazaki et al., Biochim Biophys Acta 2008 (Prostatic Neoplasms) : Leptin activates JNK, STAT3 and Akt in a biphasic manner with a similar time-course
Abdennebi-Najar et al., The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2011 : Systemically administered PEG-MLA effectively blocks leptin signal induction of hypothalamic JAK-STAT signaling
Lu et al., Fish Physiol Biochem 2012 : Overall, our results provided evidence that Lep directly stimulated JAK-STAT signaling mediated lipolysis and fatty acid ß-oxidation gene expression in the fatty degenerated hepatocytes of C. idellus and inhibited the adipogenesis mediated by the IRS-PI(3)K signaling pathway
Vaisse et al., Nat Genet 1996 : The activation of STAT proteins in response to leptin was assayed in a variety of mouse tissues known to express Ob-R ... Leptin did not induce STAT activation in any of the other tissues tested