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LEP — NOS2

Text-mined interactions from Literome

Okuya et al., Endocrinology 2001 : Moreover, 5 nM leptin reduced the triglyceride content and suppressed inducible nitric oxide synthase mRNA expression in incubated islets
Konturek et al., J Physiol Pharmacol 2001 (Stomach Ulcer) : The i.c.v. administration of LPS did not upregulate further the iNOS expression, and dose-dependently inhibited the leptin mRNA expression in gastric mucosa
Gómez-Ambrosi et al., FEBS Lett 2004 : Leptin responsiveness to LPS in iNOS-/- mutants is preserved, showing that the LPS induced rise in leptin is independent of the presence of functional iNOS
Zerani et al., J Endocrinol 2005 : Leptin receptor expression and in vitro leptin actions on prostaglandin release and nitric oxide synthase activity in the rabbit oviduct ... In this study, we have examined the presence and the distribution of receptors for leptin ( Ob-R ) in the oviduct of rabbits, and the effects of leptin on the release of prostaglandin ( PG ) F2alpha and PGE2 and on the activity of nitric oxide ( NO ) synthase ( NOS ) by oviducts cultured in vitro
Otero et al., Arthritis Res Ther 2005 : Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes : synergistic effect of leptin with interleukin-1 ... The objective of the present study was to investigate the effect of leptin , alone or in combination with IL-1, on nitric oxide synthase (NOS) type II activity in vitro in human primary chondrocytes, in the mouse chondrogenic ATDC5 cell line, and in mature and hypertrophic ATDC5 differentiated chondrocytes
Mattace Raso et al., Neurosci Lett 2006 (Glioma) : Here we investigated the in vitro effect of leptin on inducible nitric oxide synthase (iNOS) expression in a glioma cell line ( C6 ) ... Pyrrolidine dithiocarbamate ( PDTC ) and N-alpha-tosyl-L-lysine chloromethyl ketone ( TLCK ), two inhibitors of NF-kappaB activation, as well as the specific proteasome inhibitor MG132, blocked leptin induced iNOS
Rodríguez et al., Endocrinology 2007 : Accordingly, leptin increased iNOS protein expression, with a comparable time course with that of NO production and NOS activity ... Moreover, either the JAK2 inhibitor, AG490, or the PI3K inhibitor, wortmannin, significantly ( P < or = 0.05 ) abrogated the leptin induced increase in iNOS protein
Otero et al., Life Sci 2007 : Phosphatidylinositol 3-kinase, MEK-1 and p38 mediate leptin/interferon-gamma synergistic NOS type II induction in chondrocytes
Procopio et al., Endocrinology 2009 : Leptin stimulated endothelial nitric-oxide synthase via an adenosine 5'-monophosphate activated protein kinase/Akt signaling pathway is attenuated by interaction with C-reactive protein
Rodríguez et al., Mediators Inflamm 2010 : Despite a similar leptin induced iNOS up-regulation, VSMCs from SHR showed an impaired NOS activity and NO production induced by leptin, and an increased basal Nox2 expression
Donato et al., Endocrinology 2010 : Leptin induces phosphorylation of neuronal nitric oxide synthase in defined hypothalamic neurons
Chatterjee et al., J Hepatol 2013 (Disease Models, Animal...) : These results, for the first time, suggest that leptin action in macrophages of the steatotic liver, through induction of iNOS and NADPH oxidase, causes peroxynitrite mediated oxidative stress thus activating Kupffer cells