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JUN — TRAF2
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Knecht et al., Oncology 2001
(Cell Transformation, Neoplastic...) :
TRAF2 mediated NF-kappaB activation,
AP-1 induction and JAK3/STAT activation may
result in sustained proliferation leading to lymphoma
Lee et al., J Biochem Mol Biol 2002
:
The
AP1 activation by TRAF2,
TRAF5 , and TRAF6 was also greatly suppressed by the dominant negative TAK1
Guasparri et al., EMBO Rep 2006
:
TRAF2 and TRAF3 are
required for induction of NF-kappaB and associated cell survival, as well as
Jun amino-terminal kinase phosphorylation by vFLIP, whereas TRAF1, TRAF5 and TRAF6 are dispensable
Blackwell et al., Mol Cell Biol 2009
(Lymphoma) :
Notably,
TRAF2 phosphorylation
increased both basal and inducible
c-Jun and NF-kappaB activities and rendered cells resistant to stress induced apoptosis
Hagemeier et al., J Virol 2011
:
Furthermore, we show that TRAF2 is required for Na induction of lytic gene expression, that Na induces
Jun N-terminal protein kinase (JNK) activation in a
TRAF2 dependent manner, and that a JNK inhibitor abolishes the ability of Na to disrupt viral latency