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JUN — PRL

Text-mined interactions from Literome

Olazabal et al., Mol Endocrinol 2000 : Using PRLR mutants and the PRLR short form, we have found that both homodimerization of PRLR wild type and the integrity of box-1 and C-distal tyrosine of PRLR intracellular domain are needed in PRL induced proliferation and AP-1 activation ... We found that Dex negatively regulates PRL induced proliferation and AP-1 site activation ... The PRL induced c-Jun of AP-1 transcriptional complex diminishes in the presence of Dex in a dose dependent manner ... Despite the fact that the regulation of the AP-1 site is complex, we found that PRL activates the c-Jun amino terminal kinase (JNK) , while glucocorticoid prevents this JNK activation
Carpenter et al., Endocrinology 2003 (Hyperprolactinemia) : In study four, Western blot analyses indicated that PRL increased levels of phosphorylated STATs 1 and 5, but not STAT 3, and phosphorylated ERK 1 and 2 MAPKs and c-Jun N-terminal kinase/stress activated protein kinase proteins in explanted PND 28 ovine uteri
Farrow et al., Mol Endocrinol 2004 : Previously, we have demonstrated that whereas c-Jun inhibits pituitary-specific rat prolactin ( rPRL ) promoter activity, expression of v-Jun stimulates the rPRL promoter in GH4 pituitary cells
Gutzman et al., Mol Endocrinol 2005 (Breast Neoplasms...) : Here we demonstrate that PRL and E2 cooperatively enhance the activity of AP-1 in MCF-7 derived cells
Romero-Prado et al., J Cell Biochem 2006 : In the absence of FBS and in the presence of insulin or prolactin , cells show cytoskeletal organization and an AP-1 transcription site activity resembling proliferative osteochondrocytes while cells in the presence of dexamethasone and added prolactin or TGF-beta resembled differentiated osteoblasts
Andria et al., Biochem Biophys Res Commun 2007 : Prolactin expression is induced in Jurkat T-cells by beta-catenin LEF-1, AP-1 and cAMP
Gutzman et al., Oncogene 2007 (Neoplasms) : Stat5 activation inhibits prolactin induced AP-1 activity : distinct prolactin initiated signals in tumorigenesis dependent on cell context ... Further, reduction of Stat5 protein with siRNA in T47D cells, which contain elevated Stat5, increased PRL induced AP-1 signals, transcripts for the AP-1 target, matrix metalloproteinase-2 and associated invasive behavior
Conrad et al., Mol Cell Biol 1994 : In contrast, we show that intact c-Jun expression inhibited the Ras induced activation of the prolactin promoter, defining it as a negative regulator of this pathway, whereas c-Jun was able to enhance the Ras activation of an AP-1-driven promoter in GH4 cells
Caccavelli et al., Mol Endocrinol 1998 : Transcription factor AP1 is involved in basal and okadaic acid stimulated activity of the human PRL promoter