UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

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FGFR1 — ITGAV

Pathways - manually collected, often from reviews:

OpenBEL Selventa BEL large corpus: FGFR1 → Complex of ITGAV-ITGB3 (increases, ITGAV/ITGB3 Activity)
Evidence: avb3/FGF2 interaction and endothelial cell adhesion to immobilized FGF2 lead to the assembly of focal adhesion plaques containing avb3 and FGFR1, whose presence is an absolute requirement for the activation of ERK1/2 and cell proliferation [137]. Accordingly, a direct avb3/FGFR1 interaction is required for a full response to FGF2 [138].