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IRF6 — REL
Text-mined interactions from Literome
Jeon et al., Toxicol Lett 1999
:
These data suggest that AAF inhibits iNOS gene expression by a mechanism involving a blockade of
LPS induced nuclear translocation of NF-kappa
B/Rel
Steer et al., J Biol Chem 2000
:
LPS increased nuclear c-Jun/ATF-2, NF-kappaB ( 1 ) /Rel-A, and
Rel-A/C-Rel transcription factor complexes, which bound specifically to oligonucleotide sequences from the -106 to -88 base pair ( bp ) region of the promoter
Jeon et al., J Pharmacol Exp Ther 2000
(MAP Kinase Signaling System) :
We show that radicicol, a fungal antibiotic, produces a marked inhibition of p38 kinase, nuclear
factor-kappaB/Rel ( NF-kappaB/Rel ), and inducible nitric-oxide synthase (iNOS) transcription by the macrophage line RAW 264.7 in
response to
lipopolysaccharide (LPS) ... Our data also show that the p38 kinase pathway is specifically involved in
LPS induced
NF-kappaB/Rel activation and iNOS expression because NF-kappaB/Rel DNA binding and iNOS mRNA production in the presence of a specific inhibitor of p38 kinase, SB203580, were dramatically diminished ...
LPS induced loss of inhibitory proteins IkappaB-alpha and IkappaB-beta and translocation of p65,
c-Rel , and p50 was inhibited by radicicol
Jeon et al., Immunopharmacology 2000
:
These results suggest that DEX may inhibit IL-1beta gene expression by a mechanism involving the blocking of
LPS induced
NF-kappaB/Rel and AP-1 activation
Jeon et al., Immunopharmacology 2000
:
In the present study, we investigated the role of CD14 and complement receptor type 3 ( CR3 ) in mediating NO production and
NF-kappaB/Rel activation
induced by angelan and
LPS ... Third, angelan induced strong NF-kappaB/Rel and slight AP-1 DNA binding, whereas
LPS potently
activated both
NF-kappaB/Rel and AP-1
Kang et al., J Pharmacol Exp Ther 2002
:
To further investigate the mechanism responsible for the inhibition of iNOS gene expression by silymarin, we examined the effect of silymarin on
LPS induced nuclear factor-kappaB
(NF-kappaB)/Rel activation , which regulates various genes involved in immune and inflammatory response ... In RAW 264.7 cells, the
LPS induced DNA binding activity of
NF-kappaB/Rel was significantly inhibited by silymarin, and this effect was mediated through the inhibition of the degradation of inhibitory factor-kappaB
Kang et al., Biochem Pharmacol 2004
(Sepsis) :
Moreover, the
LPS induced DNA binding activity of nuclear
factor-kappaB/Rel was also inhibited by silymarin in RAW 264.7 cells
Kang et al., Cancer Lett 2004
:
Treatment of AAF caused a dose related inhibition of
LPS induced
NF-kappaB/Rel transcriptional activation, while the transcriptional activation of AP-1, CRE and NF-IL6 was not affected by AAF ... Furthermore,
LPS induced
NF-kappaB/Rel DNA binding was also suppressed by AAF treatment
Jensen et al., Environmental health : a global access science source 2003
:
EMSAs measuring NF-kappaB binding to IL-6 promoter sequences, an event known to induce IL-6 transcription, indicated a significant decrease in the
LPS mediated
induction of DNA binding RelA/p50 and
c-Rel/p50 heterodimers in the presence of DMBA
Cieslik et al., Mol Pharmacol 2006
:
LPS/IFNgamma stimulated
C-Rel binding peaked at 4 to 8 h and declined at 24 h. Transfection of cells with a C-Rel small interfering RNA abrogated C-Rel binding at all time points
Mollah et al., J Immunol 2008
(Diabetes Mellitus, Type 1...) :
In T1DM patients, late
LPS mediated nuclear DNA binding by RelA, p50,
c-Rel , and RelB was impaired as compared with type 2 DM, rheumatoid arthritis, and healthy subjects, associated with impaired DC CD40 and MHC class I induction but normal cytokine production
Li et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2010
:
This study demonstrates the ability of magnolol, a hydroxylated biphenyl compound isolated from Magnolia officinalis, to inhibit
LPS induced expression of iNOS gene and
activation of
NF-?B/Rel in RAW 264.7 cells ... The specific p38 inhibitor SB203580 abrogated the
LPS induced
NF-?B/Rel activation, whereas the selective MEK-1 inhibitor PD98059 did not affect the NF-?B/Rel
Hwang et al., Br J Pharmacol 2013
:
O-GlcNAcylation and p50/p105 binding of
c-Rel are dynamically
regulated by
LPS and glucosamine in BV2 microglia cells ...
LPS stimulated the activation of
c-Rel , increased the O-GlcNAcylation of c-Rel and enhanced the binding of c-Rel to the NF-?B site in the iNOS promoter ; GlcN attenuated these effects of LPS ... Knockdown of OGT reduced the c-Rel O-GlcNAcylation and c-Rel-p50 interaction in
response to
LPS , but did not affect either the binding of
c-Rel to the iNOS promoter or the transcriptional activity of c-Rel
Oeth et al., Blood 1995
:
Furthermore, sodium salicylate blocked the
LPS induced proteolytic degradation of I kappa B alpha, which
prevented the nuclear translocation of
c-Rel/p65 heterodimers ... These results indicated that salicylates
inhibited LPS induction of TF gene transcription in monocytic cells by preventing nuclear translocation of
c-Rel/p65 heterodimers
Mackman et al., J Biol Chem 1994
:
Taken together, these data indicated that inhibiting nuclear translocation of
c-Rel/p65 heterodimers
prevented LPS induction of TF gene transcription in monocytic cells
Osnes et al., Thromb Haemost 1996
:
Acetylsalicylic acid and sodium salicylate inhibit
LPS induced NF-kappa
B/c-Rel nuclear translocation, and synthesis of tissue factor ( TF ) and tumor necrosis factor alfa ( TNF-alpha ) in human monocytes
Brophy et al., Immunogenetics 1998
(Lymphoma, B-Cell) :
B cells and macrophages both activate
NF-kappaB/Rel in
response to
lipopolysaccharide (LPS) , but differ in sensitivity to LPS and in downstream genes that are activated
Jeon et al., Biochem Mol Biol Int 1998
:
These results suggest that DEX may inhibit iNOS gene expression by a mechanism involving the blockade of
LPS induced nuclear translocation of NF-kappa
B/Rel
Engelmann et al., Arterioscler Thromb Vasc Biol 1999
:
In contrast,
LPS mediated nuclear binding of nuclear
factor-kappaB/Rel to a TF-specific kappaB site was inhibited by lysoPC