◀ Back to IRF6

IRF6 — PRX

Text-mined interactions from Literome

Abbas et al., Free Radic Biol Med 2009 : Here, we provide evidence that the LPS/TLR4 and the Th1 cytokine IFN-gamma pathways induce expression of PRX5 , a potent peroxide and peroxynitrite reductase, in primary macrophages ... Furthermore, deletion of TRIF, MyD88, or type I IFN receptor revealed that the LPS/TLR4 dependent increase in PRX5 expression is mediated by a TRIF-dependent/IFN-beta independent pathway
Bast et al., Free Radic Biol Med 2010 : Stimulation with LPS and IFN? increased mRNA levels of Prx 1, 2, 4, 5, and 6 in BMMs of both C57BL/6 and BALB/c mice, with Prx 1, 2, 4, and 6 more strongly induced in C57BL/6 BMMs ... Further investigations on signaling pathways in C57BL/6 BMMs demonstrated that up-regulation of Prx 5 and 6 by LPS and IFN? was associated with the activation of multiple protein kinases, most notably JAK2, PI3K, and p38 MAPK