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Petersen et al., Scand J Immunol 2000 : We also investigated the phenotypic changes and the T-cell stimulatory activity of the DCs induced by bacterial lipopolysaccharide (LPS)
Hashimoto et al., Blood 2000 : Serial analysis of gene expression ( SAGE ) was conducted in lipopolysaccharide (LPS) stimulated mature and activated DCs ( MADCs ) derived from human blood monocytes
la Sala et al., J Immunol 2001 (Inflammation) : As a result, T cell lines generated from allogeneic naive CD45RA ( + ) T cells primed with DCs matured in the presence of ATP produced lower amounts of IFN-gamma and higher levels of IL-4, IL-5, and IL-10 compared with T cell lines obtained with LPS stimulated DCs
Liu et al., J Immunol 2001 : The up-regulation of TRAIL on IFN-beta stimulated DCs partially contributed to the increased cytotoxicity of DCS : Pretreatment of TRAIL-sensitive tumor cells with caspase-3 inhibitor could significantly increase their resistance to the cytotoxicity of IFN-beta stimulated DCS : In contrast, NF-kappaB inhibitor could significantly increase the sensitivity of tumor cells to the killing by nonstimulated or LPS stimulated DCS : Our studies demonstrate that IFN-beta stimulated DCs are functionally cytotoxic
Kaisho et al., J Immunol 2001 : In this study, we have examined the effects of LPS on dendritic cells (DCs) from wild-type and several mutant mice
Schweitzer et al., Nat Biotechnol 2002 : A 51-feature RCA cytokine glass array was used to measure secretion from human dendritic cells (DCs) induced by lipopolysaccharide (LPS) or tumor necrosis factor-alpha (TNF-alpha)
Ausiello et al., J Infect Dis 2002 : Although they did not affect interleukin (IL)-10 production by lipopolysaccharide (LPS) stimulated DCs , both nPT and dPT strongly synergized with LPS for IL-12 production ... PTs plus LPS stimulated DCs secreted soluble factors fostering IFN-gamma but not IL-4 and IL-5 production by naive T cells
Gauzzi et al., J Immunol 2002 : Notably, neutralization of LPS induced, endogenous type I IFNs did not interfere with the acquisition of a fully mature surface phenotype, nor did it have a significant effect on the allostimulatory properties of LPS stimulated DCs
Fiebiger et al., J Exp Med 2002 : Extracellular accumulation of mature CatL is up-regulated by inflammatory stimuli as observed in interferon (IFN)-gamma treated macrophages and lipopolysaccharide (LPS) activated DCs
Latchumanan et al., J Immunol 2002 : Further characterization of MTSA differentiated DCs showed that they were immature in nature, as stimulation of these DCs with TNF-alpha, anti-CD40, or LPS further up-regulated the surface levels of various molecules together with an increase in their T cell stimulatory capacity
Zhang et al., Mult Scler 2002 (Encephalomyelitis, Autoimmune, Experimental...) : To generate mature DCs ( mDCs ), lipopolysaccharide (LPS) was used in the culture for 24 h. LPS stimulated DCs were phenotypically mature, which exhibited strongly upregulated CD40, B7.1, and B7.2 compared to non-LPS stimulated immature DCs ( imDCs )
Jinushi et al., J Immunol 2003 (Hepatitis C, Chronic) : Of interest is the finding that NK cell activation mediated by LPS stimulated DCs was dependent on IL-12 produced in DC/NK coculture, but that IFN-alpha stimulated DC-mediated activation was not
Jiang et al., Invest Ophthalmol Vis Sci 2003 (Autoimmune Diseases...) : However, stimulation with LPS induced these cells to become mature ( m ) DCs with higher levels of surface major histocompatibility complex ( MHC ) -II and costimulatory molecules and higher mRNA expression of IL-1alpha, -1beta, -6, and -12
Fritsche et al., Blood 2003 : Accordingly, DCs showed low constitutive production of 1,25 ( OH ) 2D3, but activation by LPS increased 1,25 ( OH ) 2D3 synthesis
Gorski et al., Mol Immunol 2003 : Endogenous CCL17 and B7-DC mRNAs were increased similarly in IL-4 cultured DCs but only CCL17 was induced by LPS
Chen et al., Blood 2004 : CsA impairs chemokine receptor and cyclooxygenase-2 (COX-2) expression normally triggered in LPS stimulated DCs ; administration of exogenous prostaglandin E2 ( PGE2 ) reverses the effects of CsA on chemokine receptor expression and DC migration
Xie et al., J Immunol 2003 : LPS , a Gram negative bacterial cell wall component, has been shown to fully activate DCs both in vitro and in vivo ... In this study we investigated the role of LPS in the in vitro generation of immature DCs
Takahashi et al., Cancer Immunol Immunother 2004 (Adenocarcinoma...) : Monocyte derived DCs were generated in a culture of monocyte with interleukin 4 (IL-4) and granulocyte-macrophage colony stimulating factor, and the maturation of DCs was induced by either lipopolysaccharide (LPS) or a proinflammatory cytokine cocktail : tumor-necrosis factor alpha, prostaglandin E2, IL-6, and IL-1beta
Johansson et al., Scand J Immunol 2004 : To the contrary, simultaneous stimulation of control DCs with 4N1K and LPS + interferon-gamma did not alter IL-12 production
Long et al., Am J Respir Crit Care Med 2004 (Asthma) : LPS stimulated monocyte derived DCs from individuals with asthma exhibited increased PGE2 and IL-10 production, but equivalent IL-12 p70 synthesis, when compared with DCs from normal subjects
Nakahara et al., Int Immunol 2004 : However, SP600125 did not affect the LPS induced up-regulation of allostimulatory capacity of DCs
Rossi et al., Int Immunol 2004 : Nevertheless, LPS potently induced DCs to produce TNF and IL-12, but SAg did not, even though they efficiently activated DCs
Kamath et al., J Immunol 2005 : Production of IFN-gamma by NK cells could be stimulated by DCs from TLR agonist injected mice, and although soluble factors secreted by LPS stimulated DCs were sufficient to induce IFN-gamma, maximal IFN-gamma production required both direct contact of NK cells with DCs and DC-secreted cytokines
Kawamura et al., Immunology 2005 : Interestingly, DCs preincubated with ABH and then stimulated with LPS augmented T helper type 1 responses in culture with allogeneic T cells as compared to LPS stimulated but non-ABH pretreated DCs
Iwamoto et al., J Leukoc Biol 2005 : In contrast, DCs exposed to IL-4 before LPS stimulation or LPS stimulated DCs not exposed to washing stress before activation failed to express CD70 and did differentiate into exhausted DCs
Chen et al., Blood 2005 : Furthermore, the calcium mobilization and chemotactic responses of LPS stimulated DCs to secondary lymphoid tissue chemokine ( SLC ) /CC chemokine ligand 21 (CCL21) were significantly lower in TPT treated than untreated DCs, in association with lower chemokine receptor 7 (CCR7) and higher CCR5 expression
Maroof et al., Immunology 2005 : Stimulation of the DCs with lipopolysaccharide (LPS) for the last 24 hr of culture, or exposure to 1-15 ng/ml of interleukin (IL)-4 during development, resulted in production of DCs not only with an increased ability to stimulate T cells but also with an increasingly lacy appearance on transmission electron microscopy, with multiple unstained areas in the cytoplasm
Tsujimoto et al., J Leukoc Biol 2005 : It is interesting that flagellin injection enhanced myeloid ( CD8alpha ( -1 ) ) and plasmacytoid ( plasmacytoid DC antigen ( + ) B220 ( + ) ) DC subsets, whereas LPS only increased myeloid DCs in the draining lymph node
Allakhverdi et al., Allergy 2005 : In sharp contrast to LPS stimulated DCs , pollen treated DCs did not produce cytokines [interleukin (IL)-10, IL-12, tumor necrosis factor (TNF)-alpha ] but retained the ability to secrete high levels of these cytokines upon simulation with soluble CD40 ligand and interferon (IFN)-gamma
Vassallo et al., J Immunol 2005 : In contrast, IL-10 secretion by LPS activated CSE conditioned DCs was enhanced when compared with control DCs
Ramirez et al., Cell Stress Chaperones 2005 : Thus, despite the fact that both LPS and Gp96 activate DCs in a TLR4 dependent manner, the experiments of this study clearly demonstrate qualitative differences in the outcome of this maturation process, which preferentially favors the expansion of CD8 positive T cells
Giordano et al., Blood 2006 : We found that the nitric oxide ( NO ) donor NOR4 provides a signal allowing LPS stimulated DCs to migrate toward CCL19
Yasutomi et al., J Immunol 2005 : EM selectively suppressed activation of DCs induced by LPS and poly ( I:C ) in different ways, suggesting that the immuno modulating effects of EM depend on the nature of pathogens
Matsue et al., J Immunol 2006 : LPS- plus IFN-gamma induced activation of DCs ( assessed by CD40 expression ) was observed when there was cell-to-cell contact and was significantly blocked by heptanol, a gap junction blocker
Litjens et al., Br J Dermatol 2006 : For this purpose we measured cytokine production by these LPS stimulated cells ( MMF-DCs ) using enzyme linked immunosorbent assays as well as their ability to activate naive Th lymphocytes
Frascaroli et al., J Leukoc Biol 2006 (Cytomegalovirus Infections...) : Immature and lipopolysaccharide (LPS) stimulated DCs obtained from patients actively infected with HCMV expressed significantly lower levels of major histocompatibility complex ( MHC) class II molecules
Hoarau et al., J Allergy Clin Immunol 2006 : Moreover, BbC50SN inhibited the effects of LPS on DCs , both in terms of IL-12 production and in terms of survival
Zheng et al., Nan Fang Yi Ke Da Xue Xue Bao 2006 : After incubation for 24 hours in a incubator containing 5 % CO ( 2 ) at 37 degrees C, the DCs were stimulated by lipopolysaccharide (LPS) , and RelB gene expression in DCs were then detected by RT-PCR and immunofluorescence
Strengell et al., J Leukoc Biol 2006 : Here, we have analyzed the effect of IL-21 and IFN-gamma on lipopolysaccharide (LPS) induced maturation and cytokine production of human monocyte derived DCs
Li et al., Am J Chin Med 2006 : Morin reduced the production of IL-12 and TNF-alpha in BM-DCs , in response to LPS stimulation
Tan et al., Virology 2007 (Paramyxoviridae Infections) : Stimulation of hMPV infected DCs with LPS resulted in the enhanced expression of all these surface markers indicating that hMPV is not generally suppressing DC maturation
Yadav et al., J Leukoc Biol 2006 : Here, it is shown that DCs can be activated in response to LPS through a bystander mechanism
Tsujimoto et al., Immunol Lett 2006 : LPS treated DCs could not produce IL-12p70 in response to subsequent both LPS- and CpG DNA-stimulation
Li et al., Chin Med J (Engl) 2006 (Autoimmune Diseases...) : However, stimulation with LPS induced these cells to become mature ( m ) DCs with higher levels of surface major histocompatibility complex ( MHC ) -II and costimulatory molecules
Pepe et al., Curr Pharm Des 2006 : IL-12 production was evaluated by an ELISA in supernatants from 48 h Leishmania infected or lipopolysaccharides (LPS) stimulated DCs and MOs, also in the presence of phytohemagglutinin activated or inactivated CD4+ T cells
Li et al., Blood 2007 (MAP Kinase Signaling System) : To gain insight into cord blood ( CB ) DC immunology, we compared chemotactic responses of mature monocyte derived DCs and maturation agent lipopolysaccharide (LPS) induced signaling between CB and adult blood ( AB )
Williams et al., J Allergy Clin Immunol 2007 : This contrasted with the T ( H ) 1 polarizing effects of LPS on DCs
Chorny et al., Ann N Y Acad Sci 2006 (Autoimmune Diseases) : In contrast, VIP reduces both CD86 and CD80 expression on lipopolysaccharide (LPS) stimulated DCs , and inhibits the capacity of DCs to induce in vitro or in vivo T cell proliferation
Zhao et al., Int Immunopharmacol 2007 (Translocation, Genetic) : Lipopolysaccharide (LPS) induced DCs , exposed to sinomenine or only medium, were tested for their maturation parameters, cytokine expression, mixed lymphocyte reaction, activity and translocation of nuclear factor-kappa B (NF-kappaB) and phosphorylation of p38 stress activated protein kinase ( p38SAPK )
Mariani et al., J Immunol 2007 : At a functional level, Bet.-APE increased the capacity of LPS stimulated DCs to attract Th2 cells, whereas the capacity to recruit Th1 cells was reduced
Li et al., Blood 2007 : LPS stimulated TGF-M-DCs induced T-cell tolerance/anergy as effectively as M-DCs
Jordan et al., J Infect Dis 2007 (Boutonneuse Fever) : Transfer of rickettsiae stimulated DCs protected mice from lethal rickettsial challenge by limiting rickettsial proliferation in vivo, whereas partial protection was observed in mice receiving lipopolysaccharide (LPS) stimulated DCs
Das et al., J Biomed Mater Res A 2008 : Expression of ICAM-1 ( intercellular adhesion molecule ), a key molecule in DC-T cell interaction was increased in mature DCs in response to lipopolysaccharide (LPS)
Lapteva et al., Cancer Res 2007 : Moreover, use of iCD40 modified and LPS stimulated DCs led to targeted expansion of autologous T cells against tumor associated antigens, including prostate-specific membrane antigen, and elimination of preestablished tumors, supporting this technology as a potent strategy for DC-based cancer immunotherapy
Salazar et al., Ann Rheum Dis 2008 (Arthritis, Experimental...) : After CIA induction, mice were injected at day 35 with a single dose of 4- or 24-h LPS stimulated DCs that had been loaded with CII ( 4hLPS/CII/DCs or 24hLPS/CII/DCs )
Granzotto et al., World J Gastroenterol 2007 (Crohn Disease) : NOD2 genotype was assessed in all subjects, and we observed high CD86 expression on immature and LPS stimulated DCs in NOD2 mutated CD patients, as compared with wtNOD2 CD patients and controls
Ohtani et al., Blood 2008 (Leishmaniasis, Cutaneous) : We show here that 2 signaling pathways downstream of PI3K, mammalian target of rapamycin (mTOR) and glycogen synthase kinase 3 ( GSK3 ), differentially regulate the expression of IL-12 in lipopolysaccharide (LPS) stimulated DCs ... Rapamycin, an inhibitor of mTOR, enhanced IL-12 production in LPS stimulated DCs , whereas the activation of mTOR by lentivirus mediated transduction of a constitutively active form of Rheb suppressed the production of IL-12
Wan et al., Arthritis Rheum 2008 (Disease Models, Animal...) : LPS stimulated or anti-CD40 stimulated DCs from B6.TC mice increased B cell proliferation, antibody production, and chemokine receptor expression as compared with DCs from B6 mice
Wheat et al., J Immunol 2008 : When exposed to MAX, both resting and LPS stimulated dendritic cells (DCs) show reduced CD80 and CD86 expression on most DCs in vitro ... Furthermore, MAX treatment promoted secretion of type 2 cytokines ( IL-6 and IL-10 ) while reducing production of type 1 cytokines ( IL-12p40, TNF-alpha, and IFN-gamma ) by LPS stimulated DCs ... MAX treatment of LPS stimulated DCs also prevented optimal surface expression of CCR7 in vitro
Jaen et al., Immunology 2009 (Arthritis, Experimental) : In comparison with LPS stimulated DCs , plasmid stimulated DCs expressed lower levels of major histocompatibility complex ( MHC) class II, CD40, CD80 and CD86 molecules and secreted less IL-12p70, interferon (IFN)-gamma, IL-10 and TNF-alpha, displaying a semi-mature phenotype
Chou et al., DNA Cell Biol 2008 (Legionnaires' Disease) : Bacillus anthracis produces lethal toxin ( LT ) and edema toxin ( ET ), and they suppress the function of LPS stimulated dendritic cells (DCs)
Powell et al., Brain Behav Immun 2009 : In addition, DCs from SDR mice produced comparatively higher TNF-alpha, IL-6, and IL-10 in response to in vitro stimulation with LPS and CpG DNA
Charoensap et al., Trans R Soc Trop Med Hyg 2008 (Melioidosis) : We also found that, although the LPS mutant could readily activate monocyte derived human DCs , it induced lower levels of IL-12p70 and IL-10 production than its wild-type counterpart ( P < 0.01 )
Correa et al., J Leukoc Biol 2009 (Crohn Disease) : Study of IL-10 production by isolated cell subsets showed that DCs , but not CD4 ( + ) T cells, from penetrating Crohn 's disease produced significantly less IL-10 in response to LPS
Faugaret et al., Transplant Proc 2009 : Human monocyte derived DCs were activated by LPS in the presence or absence of MPA
Rank et al., J Allergy Clin Immunol 2009 : Anti-ST2 antibody inhibited IL-6 production from IL-33 activated DCs by approximately 60 % ; anti-ST2 did not affect IL-6 production from LPS activated DCs
Jung et al., Int J Immunopathol Pharmacol 2009 : We observed that apicidin significantly attenuated surface molecule expression in LPS stimulated DCs , suppressed production of interleukin (IL)-12 and proinflammatory cytokines ( IL-6 and TNF-alpha ) by DCs, and reduced IFN-gama production by T cells
Yang et al., Mol Immunol 2009 (MAP Kinase Signaling System) : Furthermore, exposure to LT resulted in a decrease in the expression of pro-inflammatory cytokines including IL-6, TNF-alpha, and IL-12p40 in LTA stimulated DCs as in LPS stimulated DCs ... These results suggest that LT suppresses the maturation and activation of DCs stimulated with LTA, similar to the suppression in the LPS stimulated DCs , but via a distinct mechanism
Correale et al., J Immunol 2009 (Multiple Sclerosis...) : SEA suppressed the LPS induced DCs production of IL-1beta, IL-6, IL-12, and TNF-alpha and enhanced TGF-beta as well as IL-10 production
Liu et al., Immunology 2010 (Asthma...) : GF2 treatment on LPS activated DCs suppressed naïve CD4 ( + ) T-cell proliferation and Th2 cell polarization with IL-10 production in an allogeneic mixed lymphocyte reaction
Patenaude et al., Cell Mol Life Sci 2010 (Burns) : The altered TLR4 expression on LPS stimulated CD8alpha ( + ) DCs was associated with reduced capacity to produce IL-12 after stimulation
Kim et al., Cell Immunol 2010 : Pre-treatment with TSA and ST reduced the syngeneic and allogeneic-antigen presenting activity of LPS stimulated DCs in a dose dependent manner to statistical significance ... Moreover, TSA and ST reduced the IL-2 production from LPS stimulated mature DCs
Gomard et al., PloS one 2010 (Inflammation) : We identified a novel role for JunB -- that is, induction of proinflammatory cytokines in LPS activated primary DCs with NF-kappaB acting not only as an inducer of JunB, but also as its transcriptional partner
Turnquist et al., Blood 2010 (Inflammation) : Despite high IL-12p70 secretion, rapamycin conditioned, LPS stimulated DCs remained poor T-cell stimulators, failing to enhance allogeneic Th1 cell responses ... We also report that inhibition of GSK-3 impedes the ability of LPS stimulated DCs to induce forkhead box p3 in CD4 ( + ) CD25 ( - ) T cells, as does the absence of IL-12p40/p70
Huang et al., J Immunol 2010 : Furthermore, quercetin abrogated the ability of LPS stimulated DCs to induce Ag-specific T cell activation, both in vitro and in vivo
Reuter et al., J Virol 2010 (HIV Infections...) : Here we report that M. tuberculosis exposure increases HIV trans-infection and induces viral sequestration within surface-accessible compartments identical to those seen in LPS stimulated DCs
Bles et al., Blood 2010 (Carcinoma, Lewis Lung) : Supernatants of LPS+ATP?S stimulated DCs induced smooth muscle cell and Lewis Lung Carcinoma ( LLC ) cell growth in vitro ... The coinjection of LPS+ATP?S stimulated DCs or their supernatants with LLC cells increased tumor weight in mice compared with LPS treated DCs
Lapteva et al., Methods Mol Biol 2010 : This result suggests that the use of iCD40 modified and LPS stimulated DCs is a potent strategy in DC-based cancer immunotherapies
Martins et al., J Leukoc Biol 2011 : Finally, splenic DCs of GR-1 injected mice produced less IL-12/23 p40 than those of PBS injected mice in response to LPS ex vivo, and this was at least partially dependent on exposure to GR-1 induced G-CSF in vivo
den Hartog et al., PloS one 2011 : Recombinant bovine IL-10 inhibited TLR induced activation of monocytes, and dose-dependently inhibited LPS induced activation of monocyte derived DCs comparable to human IL-10
Li et al., J Cell Physiol 2011 (Inflammation...) : The present study investigates how HNK affects lipopolysaccharide (LPS) stimulated human monocyte derived DCs ... Our experimental results show that HNK inhibits the inflammatory response of LPS induced DCs by ( 1 ) suppressing the expression of CD11c, CD40, CD80, CD83, CD86, and MHC-II on LPS activated DCs, ( 2 ) reducing the production of TNF-a, IL-1ß, IL-6, and IL-12p70 but increasing the production of IL-10 and TGF-ß1 by LPS activated DCs, ( 3 ) inhibiting the LPS induced DC-elicited allogeneic T-cell proliferation, and ( 4 ) shifting the LPS induced DC-driven Th1 response toward a Th2 response ... Further, our results show that HNK inhibits the phosphorylation levels of ERK1/2, p38, JNK1/2, IKKa, and I?Ba in LPS activated DCs ... Collectively, the findings show that the anti-inflammatory actions of HNK on LPS induced DCs are associated with the NF-?B and mitogen activated protein kinase ( MAPK ) signaling pathways
Kis-Toth et al., J Immunol 2011 : More importantly, we report for the first time, to our knowledge, that human dsDNA activated DCs, rather than LPS- or inflammatory cytokine mixture activated DCs , represent the most potent inducers of naive CD4 ( + ) T cells to promote Th1-type cytokine production and generate CD4 ( + ) and CD8 ( + ) cytotoxic T cells
Ishikawa et al., Nihon Arukoru Yakubutsu Igakkai Zasshi 2011 : Acute ethanol consumption results in a significant decrease in IL-12 production in LPS stimulated DCs and a CD40/CD40L interaction between CD40 on the DCs and CD40 ligand expressed on activated T cells ... However, ethanol inhibited IL-12 production in LPS stimulated DCs devoid of IL-10 ( IL-10/DC ), suggesting that down-regulation of IL-12 by ethanol is independent of the IL-10 levels
Song et al., Mol Immunol 2011 : Depletion of AQP3 did not affect the development of bone marrow derived DCs ( BM-DCs ) by GM-CSF or the Flt3 ligand and the level of expression of CD86 on unstimulated and LPS stimulated BM-DCs ... In the dermis, more CD103 expressing cells were detected in AQP3 ( -/- ) mice than in wild type mice and the LPS induced decrease of CD103 ( + ) dermal DCs was impaired in AQP3 ( -/- ) mice
Ogino et al., Cancer Immunol Immunother 2012 (Anoxia) : Mature DCs ( mDCs ) were induced with LPS
Zhao et al., Immunol Invest 2012 : MSCs induced DCs (MSC-DCs) can hardly stimulate T-cell proliferation even when MSC-DCs are stimulated by LPS
Yum et al., Toxicol Appl Pharmacol 2011 : Isoflavones ( formononetin, daidzein, equol, biochanin A, genistein ) were found to differentially affect the expression of CD86, a costimulatory molecule, on lipopolysaccharide (LPS) stimulated DCs ... In particular, daidzein significantly and dose-dependently inhibited the expression levels of maturation associated cell surface markers including CD40, costimulatory molecules ( CD80, CD86 ), and major histocompatibility complex class II ( I-A ( b ) ) molecule on LPS stimulated DCs ... Furthermore, daidzein enhanced endocytosis and inhibited the allo-stimulatory ability of LPS stimulated DCs on T cells, indicating that daidzein treatment can inhibit the functional maturation of DCs
Kaouther et al., ISRN pharmacology 2011 : We report that stimulation of human monocyte derived DCs with LPS strongly upregulated CD25 ( a chain of the IL2R ) expression
Terrazas et al., International journal of biological sciences 2011 : The effects of TcES upon the DCs responses to LPS were stronger if cells were exposed during their differentiation to the helminth antigens
Zhang et al., Eur J Immunol 2012 (Asthma...) : After transfer into wild-type recipient mice, the low-dose LPS activated OVA loaded dendritic cells (DCs) induced airway eosinophilia, but primed neutrophil dominated airway inflammation when TSLP-deficient DCs were used
Gárate et al., Arthritis Rheum 2013 (Arthritis, Experimental...) : CD4+ splenic T cells were transferred from mice with CIA treated with LPS stimulated DCs or from untreated mice with CIA into other mice with CIA on day 35 of arthritis ... Treatment with LPS stimulated DCs increased the numbers of interleukin-10 (IL-10) secreting and TGFß secreting CD4+ T cells, but decreased the numbers of Th17 cells ... Adoptive transfer of CD4+ T cells from treated mice with CIA reproduced the inhibition of active CIA accomplished with LPS stimulated DCs ... The therapeutic effect of LPS stimulated DCs and their influence on T cell populations were abolished when the p38 and the TGFß receptor pathways were inhibited
Yanagita et al., Eur J Oral Sci 2012 (Periodontal Diseases) : P. gingivalis LPS stimulated DCs differentiated with nicotine ( NiDCs ) induced lower T-cell proliferation and human leukocyte antigen ( HLA ) -DR expression, but elevated expression of programmed cell death ligand 1 ... These results suggest that the presence of nicotine during differentiation of DCs modulates the immunoregulatory functions of P. gingivalis LPS stimulated DCs
Berndt et al., Am J Physiol Gastrointest Liver Physiol 2012 (Colitis) : Coculture of splenocytes with LPS stimulated DCs pretreated with or without butyrate was performed and showed a significant induction of IL-17 and IL-10
Wang et al., J Clin Immunol 2013 (Disease Models, Animal...) : After 48 h, we assessed : lung tissue pathological changes ; arterial blood gas values ; purified lung DCs surface expressions of MHC-II/I-A and co-stimulatory molecules CD80, CD83, and CD86 ; lung DCs mRNA levels of chemokine receptors CCR5 and CCR7 ; lung DCs apoptosis ; lung DCs ultrastructure by transmission electron microscopy ; lung DCs NF-kB transcription factor activity ; and LPS stimulated lung DCs in vitro production of IL-12 and IL-10 were examined
Choi et al., PLoS Negl Trop Dis 2013 : The infected cells migrated much less efficiently into lymphatic vessels of ear dermis ex vivo when compared to LPS stimulated DCs
Gasparini et al., Cytokine 2013 : We thus demonstrated that the dimer RelB/p50 rather than the p50/p50 complex inhibits TNF production in LPS stimulated DCs and macrophages
Kim et al., Immunopharmacol Immunotoxicol 2013 : The DCs used in this study were derived from murine bone marrow cells, and were used as immature or lipopolysaccharide (LPS) stimulated mature DCs ... ß-GA was shown to significantly suppress the expression of surface molecules CD80, CD86, major histocompatibility complex ( MHC ) class I and MHC class II as well as the levels of interleukin-12 production in LPS stimulated DCs
Singer et al., PloS one 2013 (Inflammation...) : Significant basal production of NPY was observed in cultured bone marrow derived macrophage and dendritic cells (DCs) and was increased with LPS stimulation
Fu et al., PloS one 2013 (Inflammation) : Acetylcorynoline significantly inhibited the secretion of tumor necrosis factor-a, interleukin-6, and interleukin-12p70 by LPS stimulated DCs ... The expression of LPS induced major histocompatibility complex class II, CD40, and CD86 on DCs was also decreased by acetylcorynoline, and the endocytic capacity of LPS stimulated DCs was restored by acetylcorynoline ... In addition, LPS stimulated DC-elicited allogeneic T-cell proliferation was blocked by acetylcorynoline, and the migratory ability of LPS stimulated DCs was reduced by acetylcorynoline
Kondylis et al., Autophagy 2013 : Using high-resolution microscopy approaches, we show that in LPS stimulated dendritic cells (DCs) , autophagosomes emerge from MHC class II compartments (MIICs) and harbor both the molecular machinery for antigen processing and the autophagosome markers LC3 and ATG16L1
Yang et al., Invest Ophthalmol Vis Sci 2013 (Uveomeningoencephalitic Syndrome) : Proinflammatory cytokines secreted by CD4 ( + ) T cells and LPS induced DCs when exposed to BBR or only vehicle were detected by ELISA
Nguyen et al., Int Immunol 2013 : In response to LPS , Ahr-deficient macrophages show increased production of pro-inflammatory cytokines, such as IL-6 and TNF-a, and Ahr-deficient DCs produce less of the anti-inflammatory cytokine IL-10
You et al., Immunobiology 2013 : DCs from old subjects ( 65-75 y ) produced significantly less TNF-a and IFN-? than young subjects ( 20-30 y ) in response to lipopolysaccharide (LPS) , but expression of maturation markers and co-stimulatory molecules was preserved
Lloberas et al., Clin Exp Immunol 2013 : Furthermore, hypoxia-DCs induced more B lymphocyte proliferation than control-iDC ( 56 % versus 9 % ), while LPS-DCs induced more CD8-lymphocyte proliferation ( 67 % versus 16 % )
Blattes et al., Proc Natl Acad Sci U S A 2013 (Pneumonia) : Mycobacterium tuberculosis mannose capped lipoarabinomannan inhibits the release of proinflammatory cytokines by LPS stimulated human dendritic cells (DCs) via targeting the C-type lectin receptor DC-specific intercellular adhesion molecule 3-grabbing nonintegrin ( DC-SIGN )
Chen et al., Clin Dev Immunol 2013 : Therefore, DXM abrogated the ability of LPS stimulated DCs to induce Ag-specific T-cell activation, as determined by their decreased proliferation and IFN- ? secretion in mixed leukocyte cultures
Garzón et al., Infect Immun 2013 (Trypanosomiasis, African) : The upregulation of major histocompatibility complex class II, CD40, CD80, and CD86 molecules, as well as the secretion of cytokines such as tumor necrosis factor alpha, interleukin-10 (IL-10), and IL-6, which are normally released at high levels by LPS stimulated DCs , is significantly reduced when these cells are cultured in the presence of the T. b. gambiense secretome
Peña et al., Clin Dev Immunol 2013 (Arthritis, Experimental) : After CIA induction, mice pretreated with DXM were injected with 4-hour LPS stimulated DCs loaded with CII ( DXM/4hLPS/CII/DCs ) ... A combined treatment, including DXM preconditioning followed by an inoculation of short-term LPS stimulated CII loaded DCs , provides an improved strategy for attenuating CIA severity