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Nishimura et al., Horm Metab Res 2006
(Bacteroidaceae Infections...) :
Although Pg and E. coli
LPS had no effect on
HMG-CoA reductase gene expression, both tumor necrosis factor-alpha and interleukin-6 (IL-6), especially IL-6 at low concentration, markedly up-regulated HMG-CoA reductase gene expression
Feingold et al., J Lipid Res 1993
:
Moreover,
LPS increases hepatic
HMG-CoA reductase mRNA levels ( low dose 3.1-fold, high dose 14.2-fold )
Memon et al., Endocrinology 1993
:
Finally, pretreatment of mice with anti-TNF antibodies, but not with an IL-1 receptor antagonist, blocked the
effect of
LPS on serum cholesterol and TG levels, hepatic cholesterol and fatty acid synthesis, and hepatic
HMG-CoA reductase activity