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CD44 — IRF6
Text-mined interactions from Literome
Gee et al., J Immunol 2002
:
Differential regulation of CD44 expression by lipopolysaccharide (LPS) and TNF-alpha in human monocytic cells : distinct involvement of c-Jun N-terminal kinase in
LPS induced
CD44 expression ...
LPS , a bacterial cell wall component,
regulates CD44 expression and may modulate CD44 mediated biological effects in monocytic cells during inflammation and immune responses ... To delineate the mechanism underlying
LPS induced
CD44 expression, we investigated the role of the mitogen activated protein kinases ( MAPKs ), p38, p42/44 extracellular signal regulated kinase, and c-Jun N-terminal kinase (JNK) by using their specific inhibitors ... Taken together, these results suggest a predominant role of JNK in
LPS induced
CD44 expression in monocytic cells
Gee et al., J Biol Chem 2003
:
Although
lipopolysaccharide (LPS) and cytokines
induce HA-adhesive
CD44 , the molecular mechanism underlying this process remains unknown ... In this study, we show that
LPS induced
CD44 mediated HA (CD44-HA) binding in monocytes is regulated by endogenously produced tumor necrosis factor (TNF)-alpha and IL-10 ...
LPS induced
CD44-HA binding in THP-1 cells was regulated by endogenously produced TNF-alpha ... Blocking TNF-alpha production by PD98059, a p42/44 inhibitor, significantly reduced the
LPS induced sialidase activity and
CD44-HA binding
Mishra et al., J Biol Chem 2005
(Calcium Signaling) :
We previously demonstrated that the c-Jun N-terminal kinase (JNK), a mitogen activated protein kinase ( MAPK ), differentially
regulated LPS- but not TNF-alpha induced
CD44 expression in monocytic cells ... In this study, our results suggest that the calcium signaling pathway, in particular calmodulin (CaM) and CaM dependent protein kinase II (CaMK-II), is involved in TNF-alpha- but not
LPS induced
CD44 expression ... CD44 promoter analysis suggested the participation of distinct transcription factors AP-1 and Egr-1 in TNF-alpha- and
LPS induced
CD44 expression, respectively ... Furthermore, TNF-alpha induced CD44 expression was regulated by AP-1 through the activation of the CaMK-II pathway, whereas
LPS induced
CD44 transcription was regulated specifically by Egr-1 through JNK activation
Liang et al., J Immunol 2007
(Acute Disease...) :
In this study, we examined the
role of
CD44 in acute pulmonary inflammation and in the regulation of
LPS-TLR signaling
Swerlick et al., J Invest Dermatol 1991
:
ICAM-1, but not LFA-3 or
CD44 , was
increased in expression in a dose- and time dependent manner by interleukin 1 (IL-1) alpha, tumor necrosis factor (TNF) alpha,
lipopolysaccharide (LPS) , or interferon (IFN) gamma