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ARF6 — IRF6

Text-mined interactions from Literome

Cunningham et al., J Immunol 2002 (Acute Kidney Injury...) : Therefore, TNF is a key mediator of LPS induced ARF , acting through its receptor TNFR1 in the kidney
Cunningham et al., J Immunol 2004 (Acute Kidney Injury) : In contrast to C3H/HeOuJ controls, C3H/HeJ mice were completely resistant to LPS induced ARF ( 6-h BUN of 32.3 +/- 1.1 vs 61.7 +/- 5.6 mg/dl ) ... Transplant studies showed that C3H/HeJ recipients of wild-type kidneys ( n = 9 ) were protected from LPS induced ARF , while wild-type recipients of C3H/HeJ kidneys ( n = 11 ) developed severe LPS induced ARF ( 24-h BUN 44.0 +/- 4.1 vs 112.1 +/- 20.0 mg/dl )
Boffa et al., J Am Soc Nephrol 2004 (Acute Kidney Injury...) : This study tested whether TxA ( 2 ) receptor blockade, with the use of TxA ( 2 ) receptor knockout ( TP-KO ) mice or a selective TP receptor antagonist ( SQ29,548 ), would alleviate LPS induced renal vasoconstriction and ARF
Guo et al., J Am Soc Nephrol 2004 (Acute Kidney Injury...) : In previous work, it was demonstrated that apoptosis occurs in the kidney during LPS induced acute renal failure ( ARF ) ... However, the relative importance of apoptosis in LPS induced ARF remained unproven ... Because the caspase enzyme cascade is responsible for carrying out apoptosis, it was hypothesized that treatment with a caspase inhibitor would protect mice from LPS induced ARF ... Thus, caspase inhibition may protect against LPS induced ARF not only by preventing apoptotic cell death but also by inhibiting inflammation
Singbartl et al., J Am Soc Nephrol 2005 (Acute Kidney Injury...) : For further elucidation of the mechanisms of interactions between them, a murine model of LPS induced ARF was used
Tiwari et al., American journal of physiology. Renal physiology 2005 (Acute Kidney Injury...) : The present studies were undertaken to examine the roles of nitric oxide ( NO ) and caspase activation on renal peritubular blood flow and apoptosis in a murine model of LPS induced ARF ... Taken together, these data suggest NO-mediated activation of renal caspases and the resulting disruption in peritubular blood flow are an important mechanism of LPS induced ARF
Schramm et al., J Nephrol 2005 (Acute Kidney Injury...) : To date, there are no studies on the impact of NOS substrate ( L-Arg ) and inhibitor ( L-NMMA ) on renal function in early lipopolysaccharide (LPS) induced ARF ... We conclude that exogenous L-Arg exerts beneficial effects in early LPS induced ARF in rats during drug infusion, while NOS inhibition has no influence on GFR
Schmidt et al., American journal of physiology. Renal physiology 2007 (Endotoxemia...) : Furthermore, they suggest that the downregulation of renal urea transporters during LPS induced ARF is mediated by proinflammatory cytokines and is independent from renal ischemia because of sepsis induced hypotension
Gupta et al., American journal of physiology. Renal physiology 2007 (Acute Kidney Injury...) : Taken together, these data suggest that APC can suppress LPS induced ARF by modulating factors involved in vascular inflammation, including downregulation of renal iNOS and ANG II systems
Wu et al., American journal of physiology. Renal physiology 2007 (Acute Kidney Injury) : We hypothesized that ICAM-1 facilitates renal injury in LPS induced ARF ... ICAM-1 ( -/- ) mice were significantly resistant to LPS mediated ARF , as opposed to CD18-def mice, which developed severe ARF, as did wild-type controls ( 48 h blood urea nitrogen 143 +/- 31.5, 70.8 +/- 24.4, and 185 +/- 16.6 mg/dl in wild-type, ICAM-1 ( -/- ), and CD18-def mice, respectively, P < 0.05 ) ... Depletion of neutrophils with mAb Gr-1 led to a profound exaggeration of tumor necrosis factor (TNF) release and high mortality, but neutrophil depleted mice receiving 10-fold less LPS were protected against ARF despite TNF release similar to what is normally associated with LPS induced ARF ... In conclusion, these data show that ICAM-1 plays a key role in LPS induced ARF
Cichy et al., Braz J Med Biol Res 2009 (Acute Kidney Injury...) : Lipopolysaccharide (LPS) induced ARF is associated with hemodynamic changes that are strongly influenced by the overproduction of nitric oxide ( NO ) through the cytokine mediated up-regulation of inducible NO synthase