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HLA-DRB1 — IL6
Text-mined interactions from Literome
Etienne et al., J Immunol 1999
:
MHC class II engagement in brain endothelial cells
induces protein kinase A-dependent
IL-6 secretion and phosphorylation of cAMP response element binding protein
Kitamura et al., Immunity 2005
:
IL-6-STAT3 controls intracellular
MHC class II alphabeta dimer level through cathepsin S activity in dendritic cells
Tomoda et al., Immunology 1992
(Leukemia, Myeloid) :
Among those cytokines,
interleukin-1 beta (IL-1 beta)
had a positive effect on IFN-gamma dependent induction of
MHC class II genes
Kincaid et al., J Immunol 2007
(Tuberculosis, Pulmonary) :
In addition, M. tuberculosis peptidoglycan and
IL-6 secreted by infected macrophages
inhibit IFN-gamma induction of
MHC class II in a TLR2 independent manner
Marshall et al., J Immunol 2008
(MAP Kinase Signaling System) :
During this process, cells initiate proteolytic degradation of internalized protein Ags into peptides that complex with
MHC class II (MHC II) and simultaneously
increase expression of costimulatory molecules and of cytokines such as
IL-6 , IL-12, and IL-23