Lee et al., Can J Physiol Pharmacol 2001
(Carcinoma, Hepatocellular...) :
Suppressive effects of IL-6 on MDR1 expression and activity were also observed in HuH 7 cells
Combates et al., J Biol Chem 1994
:
NF-IL6 , a member of the C/EBP family of transcription factors, binds and trans-activates the human MDR1 gene promoter ... Co-transfection of an NF-IL6 expression vector with a chloramphenicol acetyltransferase reporter gene driven by 1018 base pairs of MDR1 5'-flanking sequences demonstrated that NF-IL6 trans activated the MDR1 promoter
Combates et al., Cell Growth Differ 1997
:
These results indicate a correlation between NF-IL6 gene expression and the regulation of the MDR1 gene
Lau et al., Biochem Biophys Res Commun 1998
:
Here we report that HTLV-I mediated MDR1 activation is dependent on the presence of an NF-IL6 binding site located between base pairs -148 and -141 relative to the transcription start site