◀ Back to IL12B

IL12B — IL5

Text-mined interactions from Literome

Varga et al., J Immunol 2000 (Asthma) : IL-5 production by BAL T cells and PBMC was inhibited by IL-12 and, to a lesser extent, by IFN-gamma ... The effects of IL-12 nor IFN-gamma on IL-5 production could not be reversed by neutralizing anti-IFN-gamma or anti-IL-12 mAbs, respectively
Tang et al., J Allergy Clin Immunol 2001 (Asthma...) : Anti-IL-12 mAb enhanced IL-5 production in the cocultures from atopic nonasthmatic subjects, whereas a dose dependent suppressive effect of recombinant human IL-12 on IL-5 production was seen in atopic asthmatic subjects
Agrawal et al., Int Immunol 2005 : MUC1 expression on activated T cells was increased in the presence of IL-12 but was not affected by IFN-gamma, IL-2, IL-4, IL-5 , IL-10, IL-13 or TNF-alpha
Slade et al., Expert Opin Investig Drugs 1998 : The induction of tumour necrosis factor alpha (TNF-alpha), interferon gamma (IFN-gamma) and interleukin-12 (IL-12) leads to inhibition of IL-5 , with animal models demonstrating immune deviation away from Th2 immune responses
Koch et al., Clin Immunol 2007 (Asthma) : Furthermore, the authors have studied the IL-12 induced expression of the T ( H ) 1-associated cytokine INF-gamma and the IL-4 induced expression of the T ( H ) 2-specific cytokine IL-5 in the presence of LPS using ELISA and compared nine atopic asthmatic subjects and eleven nonatopic normal volunteers
Warren et al., J Immunol 1995 : Production of IL-5 by human NK cells and regulation of IL-5 secretion by IL-4, IL-10, and IL-12 ... IL-5 secretion, particularly in primary cultures, is augmented by IL-4 and is inhibited by IL-12 and IL-10
Hegde et al., Cell Immunol 1995 (Neoplasms, Experimental) : AK-5 tumor induced expression of interleukin-12 : role of IL-12 in NK-mediated AK-5 regression
Finkelman et al., J Exp Med 1994 (Intestinal Diseases, Parasitic...) : IL-12 stimulated IFN-gamma and IL-10 gene expression during primary and secondary N. brasiliensis infections and inhibited IL-3, IL-4, IL-5 , and IL-9 gene expression during primary infections but had little inhibitory effect during secondary infections
Iwamoto et al., Am J Respir Crit Care Med 1996 : Therefore, to determine whether IL-12 regulates antigen induced eosinophil recruitment into the airways, we studied the effect of recombinant murine IL-12 on antigen induced eosinophil infiltration into the tracheas of sensitized mice, and also the effect of IL-12 on IL-5 and interferon-gamma (IFN-gamma) levels in bronchoalveolar lavage fluid ( BALF ) from the mice
Mahanty et al., Infect Immun 1997 (Elephantiasis, Filarial) : To assess whether IL-12 could reverse the type 1 downregulation observed, the effect of recombinant human IL-12 ( rhIL-12 ) on BMA-driven IL-5 and IFN-gamma production was also evaluated
Peng et al., Cytokine 1997 : In contrast, IL-4 and IL-5 production were slightly inhibited by IL-12
Peng et al., Cell Immunol 1997 : In the presence of IL-12 , the cytokine profile was shifted to high IFN-gamma and IL-10 production and IL-4 and IL-5 production were slightly inhibited
Okano et al., Int Arch Allergy Immunol 1998 (Asthma) : We examined the effects of IL-12 on the productions of IL-5 and granulocyte/macrophage colony stimulating factor ( GM-CSF ) by antigen ( Dermatophagoides farinae, Df ) -stimulated mononuclear cells ( MNCs ) from asthmatic patients in vitro ... IL-12 enhanced IFN-gamma production and inhibited the production of IL-5 but not of GM-CSF by Df-stimulated MNCs from asthmatic patients ... Exogenous IFN-gamma directly inhibited IL-5 production by Df-stimulated MNCs and the inhibition of IL-5 production by IL-12 was partially blocked by anti-IFN-gamma antibody in culture, indicating that inhibitory effect of IL-12 on IL-5 production by antigen stimulated MNCs is partially dependent on IFN-gamma production
Lauwerys et al., Eur J Immunol 1998 (Chronic Disease...) : Although IL-12 down-regulated IL-4, IL-5 , IL-9 and IL-10 production, its inhibitory activity on Ig production could not be ascribed to down-regulation of these cytokines, as addition of saturating doses of IL-4, IL-5 and/or IL-9 did not reverse the inhibitory activity of IL-12