◀ Back to IL12B
IL12B — IL2RA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Bliss et al., J Immunol 1999
(Agranulocytosis...) :
Production of
IL-12 does not
require TNFR
p55 , and release of TNF-alpha occurs independently of IL-12
Nguyen et al., Eur J Immunol 2000
:
Inhibition of
IL-12 induced up-regulation of
CD25 by a p38 mitogen activated protein ( MAP ) kinase inhibitor, SB203580, also ablates the synergism between IL-12 and Q126D
Valenzuela et al., J Immunol 2002
:
In addition, high
CD25 expression is substantially prolonged in the
presence of
IL-12
Sivori et al., Proc Natl Acad Sci U S A 2004
:
In the
presence of
IL-12 , freshly isolated NK cells responded to double stranded RNA or unmethylated CpG DNA and expressed CD69 and
CD25 activation markers
Tchórzewski et al., Med Sci Monit 2005
(Autoimmune Diseases...) :
We analyzed reactive oxygen intermediate ( ROI ) production by peripheral blood granulocytes, the production of IL-2, IL-5, IL-10,
IL-12 , and TNF-alpha cytokines by lymphocytes, and the
activation of
CD25 , CD26, CD69, CD71, and HLA DR antigen expression
King et al., J Immunol 2005
:
Cutting edge :
IL-12 induces
CD4+CD25- T cell activation in the presence of T regulatory cells
Brahmachari et al., J Immunol 2009
:
IL-12p40 ( 2 ) dose-dependently
inhibited the expression of Foxp3 and
CD25 , but not CD4
Ueta et al., Eur J Immunol 1996
:
Recombinant human
IL-12 stimulated gammadelta T cells, but not alphabeta T cells in peripheral blood mononuclear cells, to express
CD25 on their surfaces, and to expand in number in vitro ... Anti-TNF-alpha monoclonal antibody inhibited
IL-12 induced up-regulation of
CD25 on gammadelta T cells, suggesting that endogenous TNF-alpha may play a role in IL-12 induced activation of gammadelta T cells ... Furthermore,
IL-12 up-regulated TNF receptors on gammadelta T cells in vitro : TNF-alpha binding to its receptor
induced CD25 expression on the gammadelta T cells in an autocrine or paracrine fashion, or perhaps both