◀ Back to IFNB1
IFNB1 — IRF8
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Remoli et al., J Immunol 2002
:
Once expressed,
IRF-1 may further
stimulate the transcription of
IFN-beta
Hahn et al., J Virol 2005
(Leukoplakia, Hairy) :
However,
IRF-7 dependent activity of the IFN-alpha4,
IFN-beta , and Tap-2 promoters, as well as an ISRE promoter construct, was inhibited by BZLF-1
Yasuda et al., J Immunol 2007
(Lupus Erythematosus, Systemic) :
As anticipated,
IFN regulatory factor (IRF)7 is
required for IFN-alpha and
IFN-beta production ... Unexpectedly, however,
IRF5 plays a critical role in IFN-alpha and
IFN-beta production induced not only by RNA containing immune complexes but also by conventional TLR7 and TLR9 ligands
Kotla et al., Virology 2008
:
The type I interferon ( IFN ) response requires the coordinated activation of the latent transcription factors NF-kappaB,
IRF-3 and ATF-2 which in turn
activate transcription from the
IFN-beta promoter
Schröder et al., EMBO J 2008
:
Here, we describe a novel VACV protein, K7, which can
inhibit PRR induced
IFN-beta induction by preventing TBK1/IKKepsilon mediated
IRF activation ... Therefore, this study shows for the first time the involvement of a DEAD box helicase in TBK1/IKKepsilon mediated
IRF activation and
Ifnb promoter
induction