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CXCL12 — ZAP70

Text-mined interactions from Literome

Ticchioni et al., Blood 2002 : Furthermore, CXCL12 induced time dependent phosphorylation of ZAP-70 , Vav1, and extracellular signal regulated kinases ( ERKs ) ; the latter were reduced in the absence of functional ZAP-70
Lin et al., Mol Immunol 2010 (Inflammation) : SDF-1 enhanced Zap70 phosphorylation and also stimulated binding of talin and beta1 integrin activation
Messmer et al., Blood 2011 (Leukemia, Lymphocytic, Chronic, B-Cell) : Although significant differences in the expression or turnover of CXCR4 were not observed between ZAP-70 ( + ) and ZAP-70 ( - ) cell samples, CXCL12 induced greater intracellular Ca ( 2+ ) flux and stronger and more prolonged phosphorylation of extracellular signal regulated kinase ( ERK ) and mitogen activated protein kinase/ERK kinase ( MEK ) in the ZAP-70 ( + ) CLL cells
Kremer et al., J Immunol 2011 : G alpha i2 and ZAP-70 mediate RasGRP1 membrane localization and activation of SDF-1 induced T cell functions