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CXCL12 — MMP14

Text-mined interactions from Literome

Yu et al., J Bone Miner Res 2003 (Bone Resorption) : SDF-1 versus RANKL effects on chemotaxis, transcollagen migration, MMP-9 expression and activity, OC development, and bone resorption were evaluated in RAW cells or RAW-OCs
Bartolomé et al., Cancer Res 2004 (Lymphatic Metastasis...) : Stimulation of membrane-type 1 matrix metalloproteinase ( MT1-MMP ) activity by SDF-1alpha was necessary for invasion, involving at least up-regulation in the expression of this metalloproteinase, as detected in the highly metastatic BLM melanoma cell line ... Moreover, SDF-1alpha triggered the activation of the GTPases RhoA, Rac1, and Cdc42 on BLM cells, and expression of dominant negative forms of RhoA and Rac1, but not Cdc42, substantially impaired the invasion of transfectants in response to SDF-1alpha , as well as the increase in MT1-MMP expression
Gálvez et al., J Biol Chem 2005 : CCL2 and CXCL8 significantly increased MT1-MMP surface expression, clustering, activity, and function in human ECs
Parmo-Cabañas et al., J Pathol 2006 (Multiple Myeloma...) : Increase in MT1-MMP expression, as well as induction of its membrane polarization by CXCL12 in myeloma cells, might represent potential mechanisms contributing to this invasion
Bartolomé et al., Cancer Res 2006 (Melanoma...) : Importantly, up-regulation of MT1-MMP expression by CXCL12 , a mechanism contributing to melanoma cell invasion, is blocked by knocking down Vav expression or by inhibiting Jak
Ries et al., Blood 2007 (Inflammation) : Moreover, the inflammatory cytokines TGF-beta1, IL-1beta, and TNF-alpha up-regulated MMP-2, MT1-MMP, and/or MMP-9 production in these cells, resulting in a strong stimulation of chemotactic migration through ECM, whereas the chemokine SDF-1alpha exhibited minor effects on MMP/TIMP expression and cell invasion
Shirvaikar et al., Cytotherapy 2008 : Finally, we observed that SDF-1 up-regulated the expression of both MMP-9 and MT1-MMP in CB CD34 ( + ) cells and ex vivo expanded CFU-Meg
Laird et al., Hum Reprod 2011 : Expression of CXCL12 and CXCR4 in human endometrium ; effects of CXCL12 on MMP production by human endometrial cells ... The aim of this study was to investigate CXCL12 and CXCR4 expression in human endometrium and to see if CXCL12 could affect matrix metalloproteinase ( MMP ) production by endometrial stromal and epithelial cells