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ACLY — COA3
Text-mined interactions from Literome
Guay et al., J Biol Chem 2007
:
However, because
ACL is
required for
malonyl-CoA formation, inhibition of ACL expression by shRNA-ACL decreased glucose incorporation into palmitate and increased fatty acid oxidation in INS 832/13 cells
Ma et al., J Lipid Res 2009
:
The
ACL dependent synthesis of
acetyl-CoA is thought to be an essential step for the de novo synthesis of fatty acids and cholesterol
Lee et al., Eukaryotic cell 2011
:
Our previous study on ATP citrate lyase (ACL) in Gibberella zeae revealed that
ACL dependent
acetyl-CoA production is important for histone acetylation, especially in sexual development, but is not involved in lipid synthesis
Saha et al., Am J Physiol 1997
:
Inhibition of
ATP citrate lyase with hydroxycitrate markedly
diminished the increases in
malonyl-CoA in these muscles, indicating that citrate was the major substrate for the malonyl-CoA precursor, cytosolic acetyl-CoA