Gene interactions and pathways from curated databases and text-mining

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CASP8 — ITGA2

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: CASP8 → Complex of COL1A1-ITGA2-ITGB1 (decreases, COL1A1/ITGA2/ITGB1 Activity)
    Gendron et al., J Biol Chem 2003*
    Evidence: In experiments done in Jurkat T cells and activated peripheral blood T lymphocytes, engagement of alpha2beta1 integrin with collagen type I (Coll I) was found to significantly reduce Fas-induced apoptosis and caspase-8 activation