Miyamoto et al., Proc Natl Acad Sci U S A 2006
:
We demonstrate that BDNF , acting through TrkB, directly binds and specifically activates Tiam1 by phosphorylating Tyr-829, leading to Rac1 activation and lamellipodia formation in Cos-7 cells and increased neurite outgrowth from cortical neurons
Abe et al., Proc Natl Acad Sci U S A 2012
:
Importantly, Etv1 was selectively phosphorylated by Erk1/2 in the BDNF signaling cascade, and the inhibition of this phosphorylation abrogated the BDNF induced up-regulation of the NR2C and Tiam1 genes