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BDNF — IRF6

Text-mined interactions from Literome

Barouch et al., J Neuroimmunol 2000 : Thus, LPS increased the expression of NGF, BDNF and NT-3 in splenocytes and B cells, whereas Con-A increased the mRNA of NT-3 and NT-4 in T cells and NGF expression in splenocytes
Nakajima et al., J Neurosci Res 2001 : Stimulation of the cells with lipopolysaccharide (LPS) increased BDNF secretion, and induced NGF secretion ... Pre-treatment of microglia with a PKC inhibitor, bisindolylmaleimide, suppressed LPS stimulated BDNF secretion as well as the constitutive one
Lommatzsch et al., Respir Med 2007 (Acute Disease...) : Cell culture experiments revealed that bacterial lipopolysaccharide (LPS) enhanced the release of BDNF by peripheral blood mononuclear cells of the patients at both time points
Noga et al., Clin Exp Allergy 2008 (Hypersensitivity) : Selective induction of nerve growth factor and brain derived neurotrophic factor by LPS and allergen in dendritic cells ... LPS led to an up-regulation of BDNF , while NGF was unaffected ... LPS selectively regulates the production of BDNF
Nikodemova et al., Neuroscience 2011 (Inflammation) : While LPS did not affect the expression of the growth factors VEGF or BDNF , we observed that mechanical injury ( caused by intraparenchymal injection ) induced distinct patterns of microglial activation characterized by increased expression of VEGF and down-regulation of BDNF
Wang et al., Sheng Li Xue Bao 2011 (Disease Models, Animal...) : The results showed that BDNF in the hippocampus and serum significantly increased in the smoking, LPS and smoking + LPS groups, compared to that in the control group
Gomes et al., Journal of neuroinflammation 2013 : The maximal LPS induced BDNF release was time-coincident with an LPS induced increase of the A2AR density ... Notably, removing endogenous extracellular adenosine or blocking A2AR prevented the LPS mediated increase of both BDNF secretion and proliferation, as well as exogenous BDNF induced proliferation
Miwa et al., J Neurosci Res 1997 : LPS stimulation caused a marked increase in BDNF mRNA expression in addition to a slight increment of the NT-4/5 mRNA level ; however, the NGF mRNA level was not affected ... LPS also increased BDNF-like immunoreactivity in cultured microglia, an action consistent with an elevation of BDNF mRNA ... These results demonstrate that LPS stimulates synthesis of BDNF and probably NT-4/5, specific ligands for tyrosine kinase receptor TrkB, suggesting that activated microglia, which appear in the damaged brain, participate in neuronal regeneration via production of such neurotrophins