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ATP5O — DNAJB1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Ballinger et al., Mol Cell Biol 1999
:
Recombinant CHIP inhibited
Hsp40 stimulated
ATPase activity of Hsc70 and Hsp70, suggesting that CHIP blocks the forward reaction of the Hsc70-Hsp70 substrate binding cycle
Yamagishi et al., Biochem Biophys Res Commun 2000
:
Furthermore, although Hsp105alpha and Hsp105beta did not show ATPase activity, the addition of Hsp105alpha or Hsp105beta to Hsc70/Hsp40 enhanced the amount of hydrolysis of ATP greater than that of the
Hsp40 stimulated Hsc70
ATPase activity
Liu et al., J Biol Chem 2001
:
However, a defect in the ability of
Hsp40 to
stimulate the
ATPase activity of Ssc1 -- 2 was not corrected in Ssc1 -- 201
Ngosuwan et al., J Biol Chem 2003
:
Hsp40s stimulate the
ATPase activity of Hsp70s and target unfolded proteins to Hsp70s. Genetic and biochemical evidence supports a role for cytosolic Hsp70s and Hsp40s in the post-translational translocation of precursor proteins into endoplasmic reticulum and mitochondria
Fewell et al., J Biol Chem 2004
:
Using an assay for ATP hydrolysis, we identified and screened small molecules with structural similarity to 15-deoxyspergualin and NSC 630668-R/1 for their effects on endogenous and
Hsp40 stimulated Hsp70
ATPase activity ... In contrast, three compounds inhibited the ability of
Hsp40 to
stimulate Hsp70
ATPase activity but did not affect the endogenous activity of Hsp70
Dragovic et al., EMBO J 2006
:
Hsp40s increase the low intrinsic
ATPase activity of Hsp70, and nucleotide exchange factors ( NEFs ) remove ADP after ATP hydrolysis, enabling a new Hsp70 interaction cycle with non-native protein substrate
Couturier et al., J Mol Recognit 2010
:
Hsp40 directly
enhanced hsp70
ATPase activity in an N ( TAIL ) -dependent manner, and formation of hsp40-hsp70-N ( TAIL ) intracellular complexes required the presence of N ( TAIL ) Box-2 and 3
Botha et al., Cell Stress Chaperones 2011
:
In contrast, the
Hsp40 stimulated plasmodial and human Hsp70
ATPase activities were differentially inhibited in the presence of pyrimidinone based small molecule modulators
Shorter et al., PloS one 2011
:
Optimal disaggregase activity is achieved when the
Hsp40 can
stimulate the
ATPase activity of Hsp110 and Hsp70
Höhfeld et al., Cell 1995
:
One Hip oligomer binds the ATPase domains of at least two Hsc70 molecules dependent on
activation of the Hsc70
ATPase by
Hsp40
Nagata et al., Biochemistry 1998
:
We did find that
hdj-1p , like bacterial DnaJ,
stimulated the
ATPase activity of hsp70
Raynes et al., J Biol Chem 1998
:
HspBP1 ( 8 microM ) inhibited approximately 90 % of the
Hsp40 activated Hsp70
ATPase activity