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HRH1 — MAPK11
Text-mined interactions from Literome
Pype et al., Am J Respir Crit Care Med 2001
(Bronchial Hyperreactivity) :
An inhibitor of NF-kappaB activation, pyrrolidine dithiocarbamate, and a p38
MAPK inhibitor,
blocked the IL-1beta induced
H(1)R desensitization, whereas anisomycin, an SAPK/JNK and p38 MAPK activator, mimicked the effect of IL-1beta ... Here, we have demonstrated that IL-1beta desensitizes
H(1)R , which
involves the activation of p38
MAPK and NF-kappaB, leading to the expression of cox-2 and the synthesis of PGE ( 2 )
Noubade et al., J Clin Invest 2007
(Encephalomyelitis, Autoimmune, Experimental...) :
Moreover,
H1R signaling at the time of TCR ligation was
required for activation of p38
MAPK , a known regulator of IFN-gamma expression