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BDNF — MAPK11
Text-mined interactions from Literome
Araki et al., J Neurochem 2000
:
In contrast, the level of
BDNF induced phosphorylation of
mitogen activated protein kinase and coprecipitated proteins with anti-Trk and Grb2 antibodies did not show any difference between neurons infected with these two types of Shp-2 ... In addition, the phosphatase Shp-2 may not influence the level of
BDNF induced activation of
mitogen activated protein kinase in cultured cortical neurons
Jovanovic et al., Nat Neurosci 2000
(MAP Kinase Signaling System...) :
In a synaptosomal preparation,
brain derived neurotrophic factor (BDNF) increased
mitogen activated protein ( MAP ) kinase dependent synapsin I phosphorylation and acutely facilitated evoked glutamate release
Pizzorusso et al., J Neurosci 2000
:
Finally,
BDNF caused phosphorylation of
mitogen activated protein kinase ( MAPK ), and because the treatment with the MAPK inhibitor U0126 completely abolished CREB activation and c-fos upregulation, it is likely that both processes depend mainly on the MAP kinase pathway
Araki et al., J Neurochem 2000
:
BDNF induced activation of
mitogen activated protein kinase was not altered by the expression of these proteins
Obrietan et al., J Neurophysiol 2002
:
Excitatory actions of GABA increase
BDNF expression via a
MAPK-CREB dependent mechanism -- a positive feedback circuit in developing neurons
Yamagishi et al., Brain Res Mol Brain Res 2003
(Potassium Deficiency) :
Comparison of inhibitory
effects of
brain derived neurotrophic factor and insulin-like growth factor on low potassium induced apoptosis and activation of p38
MAPK and c-Jun in cultured cerebellar granule neurons
Alder et al., J Neurosci 2003
:
BDNF mediated gene expression was tyrosine kinase B and
mitogen activated protein kinase dependent , as demonstrated by pharmacological studies
Ruiz-León et al., J Neurochem 2004
(Neuroblastoma) :
Taken together, our results suggest that simultaneous activation of at least two signalling pathways,
Ras/MAPK and PI3K/Akt, is
necessary to mediate a full activation of the APP promoter by
BDNF
Zheng et al., J Neurochem 2004
:
Western blot analyses showed that both IGF-1 and
BDNF induced the activation of the phosphatidylinositide 3 kinase (PI3)/Akt ( protein kinase B ) kinase and the
mitogen activated protein kinase ( MAPK ) pathways
Obata et al., Neuroscience 2004
(Pain...) :
Therefore, we suggest that after inflammation near the cell body, NGF synthesized within the nerve root and DRG
induces BDNF expression through trkA receptors and intracellular
ERK-MAPK
Matsumoto et al., Mol Cell Neurosci 2006
:
PLC-gamma inhibitor attenuated
BDNF stimulated long lasting
MAPK activation
Easton et al., J Neurochem 2006
(Neuroblastoma) :
Characterization and kinetic and spatial modeling of the signaling pathways underlying this prolonged
MAPK activation by
BDNF will be important in understanding the physiological role of BDNF in many complex systems in the nervous system ... In addition to Shc, fibroblast growth factor receptor substrate 2 (FRS2) is required for the
BDNF induced activation of
MAPK ... Shp2 is required for complete
MAPK activation by
BDNF , as expression of a dominant negative Shp2 in cells attenuates BDNF induced activation of MAPK
Trang et al., J Neurosci 2009
:
P2X4-receptor mediated synthesis and release of
brain derived neurotrophic factor in microglia is
dependent on calcium and
p38-mitogen activated protein kinase activation ... Furthermore, we find that the P2X4R evoked release and synthesis of
BDNF are
dependent on activation of p38-mitogen activated protein kinase (
MAPK )
Huang et al., J Biol Chem 2009
:
Moreover, Hrs-sensitive TrkB-FL recycling plays a role in
BDNF induced prolonged
mitogen activated protein kinase ( MAPK ) activation
Zadran et al., J Neurosci 2010
:
In neurons,
MAPK is
activated by both
brain derived neurotrophic factor (BDNF) and EGF
Zhang et al., Theriogenology 2010
(MAP Kinase Signaling System) :
In this study, we investigated ( using western blots ) the
effects of
BDNF on the phosphorylation of protein kinase B (PKB) and
mitogen activated protein kinase ( MAPK ) in mouse oocytes and cumulus cells cultured in vitro ... Furthermore,
BDNF increased phosphorylation of MAPK in oocytes at 16h of in vitro maturation ( P=0.0041 ), but K252a together with BDNF did not
reduce phosphorylation of
MAPK in the oocytes
Yin et al., J Neurochem 2010
:
In this study, we report RanBPM is a novel TrkB interacting protein that contributes to
BDNF induced
MAPK and Akt activation together with neuronal morphogenesis and survival ... Over-expression of RanBPM in PC1210 cells ( PC12 cells stably over expressing TrkB ) can significantly enhance
BDNF induced
MAPK and Akt activation
Bałkowiec-Iskra et al., Neuroscience 2011
(Inflammation) :
The effect of TNFa on
BDNF expression is
dependent on sodium influx through TTX-sensitive channels and on
p38-mitogen activated protein kinase
Bi et al., J Neurophysiol 2011
:
Conversely, BDNF had no effect on subsequently applied ephrin-A5-Fc or EphA5-Fc. Consistent with this, ephrin-A5-Fc also prevented
BDNF induced activation of p42/44
MAPK
Niu et al., J Neuropathol Exp Neurol 2011
:
Our results indicate that
BDNF increases telomerase expression and activity levels in SMNs and
activates mitogen activated protein kinase/extracellular signal regulated kinases 1 and 2 and phosphatidylinositol-3-OH kinase/protein kinase B signals, and their downstream transcription factors nuclear factor-?B, c-Myc, and Sp1
Zhang et al., Behav Brain Res 2012
(Disease Models, Animal...) :
Curcumin produces antidepressant effects via activating
MAPK/ERK dependent
brain derived neurotrophic factor expression in the amygdala of mice
Deogracias et al., Proc Natl Acad Sci U S A 2012
(Disease Models, Animal...) :
Ongoing synaptic activity and
MAPK signaling is
required for fingolimod induced
BDNF increase, a pathway that can also be activated in vivo by systemic fingolimod administration
Numakawa et al., Neuroscience 2013
:
In CNS neurons,
BDNF triggers activation of phospholipase C? ( PLC? ), mitogen activated protein/extracellular signal regulated kinase (
MAPK/ERK ), and phosphoinositide 3-kinase (PI3K)/Akt pathways, influencing neuronal cells beneficially through these intracellular signaling cascades
Roback et al., Eur J Neurosci 1995
:
BDNF produced an
increase in
mitogen activated protein ( MAP ) kinase tyrosine phosphorylation, MAP kinase activity, intracellular calcium concentration and c-fos expression in the glial cells