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SERPINE1 — TNF

Text-mined interactions from Literome

Cigolini et al., Atherosclerosis 1999 (Obesity) : Furthermore our data support the possibility of a main role of endogenous TNF-alpha on human adipose tissue PAI-1 expression
Sakamoto et al., Am J Physiol 1999 : To identify mechanism ( s ) through which TNF-alpha induces PAI-1 , 3T3-L1 preadipocytes were differentiated into adipocytes and exposed to TNF-alpha for 24 h. TNF-alpha selectively increased the synthesis of PAI-1 without increasing activity of plasminogen activators ... Both superoxide ( generated by xanthine oxidase plus hypoxanthine ) and hydrogen peroxide were potent inducers of PAI-1, and hydroxyl radical scavengers completely abolished the TNF-alpha induction of PAI-1 ... Because induction of PAI-1 by TNF-alpha is potentiated synergistically by insulin, both agonists appear likely to contribute to the impairment of fibrinolytic system capacity typical in obese, hyperinsulinemic patients
Swiatkowska et al., Eur J Biochem 2000 (MAP Kinase Signaling System) : In contrast to exogenously released NO that significantly reduced mostly basal PAI-1 expression, endogenously generated NO by NOS potentiated TNFalpha induced upregulation of PAI-1 expression
Birgel et al., Arterioscler Thromb Vasc Biol 2000 : Moreover, TNF-alpha and interkeukin-1beta ( IL-1beta ) also exerted a stimulatory effect on PAI-1 release and increased PAI-1 mRNA levels ... In addition, data suggest that TNF-alpha and IL-1beta also have stimulatory effects on PAI-1 protein secretion and may contribute to the elevated PAI-1 levels observed in obesity
Midorikawa et al., Biochem Biophys Res Commun 2000 (Arteriosclerosis...) : Secretion of TGFbeta ( transforming growth factor beta ) and TNFalpha ( tumor necrosis factor alpha ), possible regulators of PAI-1 expression and secretion, were not stimulated by treatment with 1.0 mM homocysteine
Lopez et al., Atherosclerosis 2000 : In TNFalpha stimulated cells, ATOR and FLU had a modest down modulating effect ( -17 and -20 %, respectively ) on TNFalpha induced increase in PAI-1 synthesis
Soeda et al., Biochim Biophys Acta 2001 : The stimulating effect of TNF-alpha on PAI-1 synthesis was attenuated by the pretreatment of HUVEC with daunorubicin ... Fumonisin B ( 1 ) treatment restored the daunorubicin induced decrease in PAI-1 release to approximately 70 % of the control, but did not affect the TNF-alpha induced increase in PAI-1 release
Peiretti et al., J Biol Chem 2001 : A reduced p70 S6 kinase ( p70 ( S6K ) ) phosphorylation was also observed and, in this situation, TNF dramatically enhanced PAI-1 synthesis ... Similarly, TNF significantly up-regulated PAI-1 synthesis when p70 ( S6K ) phosphorylation was inhibited by rapamycin
Chen et al., Thromb Haemost 2001 (MAP Kinase Signaling System) : PAI-1 gene activation by TNF-alpha apparently is yet to be defined for the location of the response element and/or the signaling pathway, while TGF-beta is the most important cytokine for PAI-1 transcriptional activation through its 5 ' proximal promoter
Montes et al., Thromb Haemost 2002 (Disseminated Intravascular Coagulation...) : Previous findings suggest that tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) are responsible for the increase in the level of PAI-1 ... These results suggest that PAI-1 increase might be independent of TNF-alpha and IL-1beta
Gruber et al., Blood 2003 (Arteriosclerosis) : Using reporter gene analysis, we could identify a region in the PAI-1 promoter that contributes to basal expression as well as to tumor necrosis factor alpha (TNFalpha) induction of PAI-1 in endothelial cells
Swiatkowska et al., Cell Mol Biol Lett 2002 : Because TNFalpha induces PAI-1 production in endothelial cells, and NAC attenuated this response, we attempted to investigate the possible involvement of ROS in the activation of PAI-1 by TNFalpha ... Upregulation of PAI-1 expression in endothelial cells by the stimulation with TNFalpha ( 50 ng/ml ) or H2O2 ( 10-200 micro M ), observed by measurement of the antigen and mRNA levels, was reversed in the presence of NAC ( 20mM )
Pawłowska et al., Cell Mol Biol Lett 2002 : We observed an inhibition of stimulatory effect of TNFalpha on PAI-1 expression also at the level of the PAI-1 promoter in cells transfected with a PAI-1 promoter fragment ( +71 to -800 )
Pandey et al., Am J Pathol 2003 : However, in lean mice, TNF-alpha induced PAI-1 expression is mediated primarily by the p55 TNFR ... These observations suggest that the p75 TNFR may play a role in attenuating TNF-alpha induced PAI-1 mRNA expression in acute inflammatory conditions
Peiretti et al., J Cell Physiol 2003 : This lack of effect was not due to a default of TNFalpha signaling since PAI-1 synthesis was still stimulated in response to exogenous TNFalpha
Nordt et al., Thromb Haemost 2003 (Arteriosclerosis) : PAI-1 gene and protein expression were induced consistently by TGF-beta ( up to 4.0-fold ), PDGF ( 2.1-fold ), TNF-alpha ( 1.7-fold ), and thrombin ( 2.3-fold )
Li et al., Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2002 : The MAPKK inhibitor ( PD98059, 60 mumol/L ) could markedly inhibit PAI-1 activity and mRNA expression induced by TNF-alpha ( 100 U/ml ) or mmLDL ( 50 micrograms/ml ) ... ( 1 ) TNF-alpha or mmLDL could induce PAI-1 activity and mRNA expression in HUVECs ... ( 2 ) Increase of PAI-1 activity induced by TNF-alpha and mmLDL was related to its mRNA expression ... ( 3 ) The MAPK pathway may play a role in PAI-1 expression induced by TNF-alpha or mmLDL
Arndt et al., Biochim Biophys Acta 1992 (Carcinoma, Hepatocellular...) : The presence of both interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF) also increased UK and PAI-1 levels, although not as dramatically as IL-1
Idell et al., Am J Respir Cell Mol Biol 1992 (Inflammation...) : HPMC PAI-1 is increased by transforming growth factor-beta ( TGF-beta ) and tumor necrosis factor-alpha (TNF-alpha) , as is tPA release, while PAI-1 mRNA is unchanged and tPA mRNA is increased
Kassis et al., Blood 1992 : Enzyme linked immunosorbent assay and immunoneutralization experiments indicate that tumor necrosis factor-alpha (TNF alpha) and interleukin-1 alpha (IL-1 alpha) do not contribute to the postoperative plasma effect on HUVEC PAI-1 synthesis
Idell et al., Am J Physiol 1992 : In dose and time-course studies, HLF plasminogen activator inhibitor-1 ( PAI-1 ) was increased by TGF-beta, whereas TNF-alpha induced release of PAI-1 into the media
Hamaguchi et al., J Pharmacol Exp Ther 2003 : TNF-alpha induced PAI-1 mRNA expression and protein production in human umbilical vein endothelial cells ( HUVECs ) ... A specific inhibitor for p38 mitogen activated protein kinase, 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) 1H-imidazole ( SB 203580 ), and a protein kinase C inhibitor, calphostin C, had no inhibitory effects on TNF-alpha induced PAI-1 secretion ... A protein tyrosine kinase inhibitor, genistein, completely inhibited TNF-alpha induced PAI-1 secretion, whereas an inhibitor of extracellular signal regulated kinase ( ERK ) kinase, 2'-amino-3'-methoxyflavone ( PD98059 ), and a nuclear factor-kappaB (NF-kappaB) inhibitor, emodin, partly inhibited TNF-alpha induced PAI-1 secretion ... Together, PD98059 and emodin completely inhibited TNF-alpha induced PAI-1 secretion, suggesting that both NF-kappaB dependent and NF-kappaB independent pathways are involved in TNF-alpha induced signal pathway to PAI-1 production and that the latter pathway is mediated by activation of ERK ... Furthermore, we have shown that troglitazone inhibited both TNF-alpha induced PAI-1 protein secretion and mRNA in HUVECs ... Genistein, but neither PD98059 nor emodin, was additive to the inhibitory effect of troglitazone on TNF-alpha induced PAI-1 secretion
Muth et al., Crit Care Med 2004 : In all EC, stimulation with tumor necrosis factor-alpha and lipopolysaccharide increased the expression of PAI-1 , PAI-2, and u-PA and decreased t-PA expression
Bauer et al., J Clin Endocrinol Metab 2004 : Induction of PAI-1 by TNF alpha could be related to restricted trophoblast invasion in preeclampsia
Hou et al., J Biol Chem 2004 : Although TNFalpha is a potent inducer of PAI-1 expression in vitro and in vivo, the precise location of the TNFalpha response site in the PAI-1 promoter has yet to be determined
Torii et al., Rinsho Byori 2005 (Glomerulonephritis...) : We also closely examined the effects of hypoxia and TNF-alpha on PAI-1 expression in cultured human proximal renal tubular cells ( HRCs )
Sopasakis et al., Int J Obes Relat Metab Disord 2005 : TNFalpha increased the mRNA levels of TNFalpha itself as well as IL-6, IL-8, IL-1beta and PAI-1 , but not leptin
Liu et al., Biochem Biophys Res Commun 2005 : Thiazolidinediones inhibit TNFalpha induction of PAI-1 independent of PPARgamma activation ... In an endothelial cell line, Rosiglitazone ( RG ) and Pioglitazone ( PG ) inhibited induction of PAI-1 by TNFalpha ... The observations suggest TZDs inhibit TNFalpha mediated PAI-1 induction independent of inducible PPARgamma activation and this may involve in the modulation of Nur77/Nurr1 expression and NP binding to the PAI-1 NBRE
Li et al., Kidney Int 2005 (Anoxia) : Synergistic effect of hypoxia and TNF-alpha on production of PAI-1 in human proximal renal tubular cells ... We also closely examined the effects of hypoxia and tumor necrosis factor-alpha (TNF-alpha) on PAI-1 expression in cultured human proximal renal tubular cells ( HPTECs ) ... TNF-alpha can synergistically enhance this hypoxia induced PAI-1 expression
Zhou et al., J Cell Biochem 2005 : We found that SalB inhibited TNF-alpha induced PAI-1 mRNA production and protein secretion in HUVECs ... Treatment with SalB ( 0.05 and 0.15 microM ) notably attenuated TNF-alpha induced expression of PAI-1 to 90.5 % and 74.6 %, respectively, after 12 h, and to 75.1 % and 64.2 %, respectively, after 18 h ... We found that the c-Jun N-terminal kinase (JNK) inhibitor, SP600125, increased the inhibitory effects of SalB on TNF-alpha induced PAI-1 secretion, whereas the nuclear factor-kappaB (NF-kappaB) inhibitor, emodin, and the extracellular signal regulated kinase ( ERK ) inhibitor, PD98059, did not ... Collectively, these results indicate that the NF-kappaB and ERK-AP-1 pathways are possible targets of SalB in the regulation of TNF-alpha stimulated PAI-1 production in HUVECs
Kimura et al., Rinsho Byori 2005 (Anoxia...) : In the present study, we examined the effects of hypoxia and TNF-alpha on PAI-1 , MCP-1 and VEGF expression in cultured human proximal renal tubular cells ( HPTECs ) ... Hypoxia, TNF-alpha and their combination induced a 2.8-fold, a 1.8-fold, and a 4.6-fold increase in PAI-1 protein secretion, and produced a 3.6-fold, a 3.3-fold, and a 12.1-fold increase at the PAI-1 mRNA level, respectively
Swiatkowska et al., FEBS J 2005 : We have shown that TNFalpha induced expression and gene transcription of PAI-1 involves a regulatory region present in segment -664/-680 of the PAI-1 promoter ... We show that activation of PAI-1 gene by TNFalpha and reactive oxygen species is mediated by interaction of NF-kappaB with the cis acting element located in the -675 4G/5G insertion/deletion in the PAI-1 promoter
Huber et al., Placenta 2006 : TNFalpha mediated induction of PAI-1 restricts invasion of HTR-8/SVneo trophoblast cells
Zhang et al., Vascul Pharmacol 2006 : Notoginsenoside R1 from Panax notoginseng inhibits TNF-alpha induced PAI-1 production in human aortic smooth muscle cells ... These results suggest that notoginsenoside R1 inhibits TNF-alpha induced PAI-1 overexpression in HASMCs by suppressing ERK and PKB signaling pathways
Slivka et al., Biochim Biophys Acta 1991 : Moreover, when PK-C was down-regulated by PMA pretreatment, subsequent induction of PAI-1 by transforming growth factor beta ( TGF beta ) and tumor necrosis factor alpha (TNF alpha) was unaltered, and induction by lipopolysaccharide (LPS) was decreased by only 50 % ... Agents which increase cAMP, ( e.g., forskolin and isobutylmethylxanthine ) blocked the induction of PAI-1 synthesis by PMA, LPS, TGF beta and TNF alpha suggesting that induction may occur by lowering cAMP
Takeshita et al., Metabolism 2006 (Diabetes Mellitus, Type 2...) : To address the mechanism underlying the up-regulation of hepatic PAI-1 in obesity, we tested the effects of tumor necrosis factor alpha (TNF-alpha) , an important link between obesity and insulin resistance, on PAI-1 production in the nonmalignant human hepatocyte cell line, THLE-5b ... A thiazolidinedione, pioglitazone, reduced TNF-alpha induced PAI-1 production by 32 %, via protein kinase C- and nuclear factor-kappaB dependent pathways ... The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor cerivastatin inhibited TNF-alpha induced PAI-1 production by 59 %, which was reversed by coincubation with mevalonic acid
Mukai et al., Am J Physiol Heart Circ Physiol 2007 : The induction of PAI-1 by TNF-alpha and insulin is mediated, in part, by ERK and p38 MAPK
Takeshita et al., Eur J Pharmacol 2008 (Diabetes Mellitus, Type 2...) : We next examined the role of the renin-angiotensin system on TNF-alpha induced PAI-1 production in the nonmalignant human hepatocyte cell line THLE-5b ... Moreover, angiotensin AT(1) receptor antagonist dose-dependently inhibited TNF-alpha induced PAI-1 production
Liu et al., J Endocrinol 2008 : Taken together, these observations suggest that GLP-1 inhibits TNF-alpha mediated PAI-1 induction in vascular endothelial cells, and this effect may involve Akt mediated signalling events and the modulation of Nur77 expression and NP binding to the PAI-1 NBRE
Kimura et al., Nephrol Dial Transplant 2008 (Inflammation) : It also enhanced hypoxia-, TNF-alpha- and hypoxia plus TNF-alpha stimulated PAI-1 expression at the mRNA and protein levels
Deng et al., J Pharmacol Exp Ther 2008 : The prolonged TNF-alpha production enhanced PAI-1 production after RAN cotreatment, and this is important for the hepatotoxicity
Ding et al., Cell Biol Int 2008 (Carcinoma, Hepatocellular...) : Ghrelin, a recently described orexigenic peptide hormone, attenuates PAI-1 induced by TNF-alpha in the human hepatoma cell line ( HepG2 ) ... Exposure to TNF-alpha ( 1 ng/ml ) for 24h caused a significant increase in PAI-1 mRNA expression and protein secretion, as evaluated by RT-PCR and ELISA, but pretreatment with ghrelin ( 1-100 ng/ml ) inhibited both basal and TNF-alpha induced PAI-1 release in a dose and time dependent manner in HepG2 ... The results indicate that ghrelin inhibits both basal and TNF-alpha induced PAI-1 production via NF-kappaB pathway in HepG2 cells, and suggest that the peptide plays a therapeutic role in atherosclerosis, especially in obese patients with insulin resistance, in whom ghrelin levels were reduced
Niiya et al., Rinsho Ketsueki 1991 (Leukemia, Promyelocytic, Acute) : As with the case of PMA, TNF-alpha and IL-6 induced PL-21 cells to macrophage-like cells, but did not affect the PAI activity
Kimura et al., Nephrol Dial Transplant 2009 (Fibrosis) : Dexamethasone enhances basal and TNF-alpha stimulated production of PAI-1 via the glucocorticoid receptor regardless of 11beta-hydroxysteroid dehydrogenase 2 status in human proximal renal tubular cells ... DXA further increased TNF-alpha stimulated PAI-1 expression via the GR
Sawdey et al., J Clin Invest 1991 : However, the greatest responses to TGF-beta were observed in adipose tissue and the kidney, while LPS and TNF-alpha strongly stimulated PAI-1 gene expression in the liver, kidney, lung, and adrenals ... These results demonstrate that the PAI-1 gene is regulated in a complex and tissue-specific manner in vivo, and suggest a role for TNF-alpha in the response of the PAI-1 gene to sepsis
Jerczynska et al., Regul Pept 2009 : Its analogue, 8-Br-cGMP alone had no effect but significantly inhibited TNFalpha induced expression of PAI-1 ... Similarly, CNP and the inhibitors of ERK1/2 ( PD098059 ) and PI3K ( LY294002 ) attenuated PAI-1 expression induced by TNFalpha
Bergh et al., Biochem Biophys Res Commun 2009 (Thrombosis) : Shear stress and TNF-alpha additively induced PAI-1 , whereas shear stress blocked the cytokine effect on t-PA and u-PA
Riedo et al., J Immunol 1990 : Neither the LPS- or TNF induced expression of PAI-1 nor the dLPS inhibition of the LPS response was mediated by prostanoids
Cao et al., Acta Diabetol 2013 : Furthermore, PAI-1 was also upregulated in the presence of TNF-a and glucose ... TNF-a induced Egr-1 protein expression and PAI-1 levels through the ERK1/2 pathway
Zou et al., Toxicology 2011 (Drug-Induced Liver Injury) : TNF had no effect on PAI-1 production or fibrin deposition
Wu et al., Circ J 2012 : In cultured human endothelial cells, GlcN time- and concentration-dependently increased PAI-1 protein level that was further enhanced by tumor necrosis factor (TNF)-a , which was accompanied by a transient synergistic activation of p38mapk ... The stimulation of PAI-1 by GlcN alone or by GlcN and TNF-a in combination was inhibited by the specific inhibitor of p38mapk, but not that of JNK or ERK1/2
Lobo et al., Cytokine 2012 : Simvastatin also attenuated the increase in expression and secretion of PAI-1 induced by TNF-a ( 16898.6 ± 1663.3 vs 12922.1 ± 843.9 and 5.19 ± 3.12 vs 0.59 ± 0.16, respectively p < 0.05 ), but under baseline conditions had no effect on the expression or secretion of PAI-1 ... Our findings suggested that simvastatin counteracted the stimulatory effect of TNF-a on secretion and expression of MCP-1, PAI-1 and adiponectin, implying a potential anti-atherogenic effect during the inflammatory process ; these pleitropic effects were more pronounced with HMG-CoA reductase inhibitor
van den Berg et al., Thromb Haemost 1988 : Cultured human endothelial cells increase their PAI-1 production upon stimulation with LPS and TNF , agents that are known to cause an increase in PAI-1 levels in vivo
van Hinsbergh et al., Blood 1988 : The monokine tumor necrosis factor ( human recombinant TNF ) increased the production of PAI by cultured human endothelial cells from umbilical vein ( twofold ) and from foreskin microvessles ( four to eight fold ) ... The stimulation of PAI activity by TNF was seen at 4 U/mL and reached a maximum at 500 U/mL ... Therefore, it is most likely that vascular endothelial cells contribute to the increased amount of circulating PAI induced by TNF in vivo
Dosne et al., Thromb Res 1988 : TNF ( 1-1000 pg/ml ) induced a dose dependent increase in PAI level in the supernatant from 6 to 25 U/ml as estimated against urokinase
Ferran et al., Biochem Biophys Res Commun 1995 : We show that pyrrolidine dithiocarbamate strongly reduces the TNF alpha mediated induction of E-selectin, VCAM-1, ICAM-1, PAI-1 , tissue factor, IL-8 and I kappa B-alpha
Panagakos et al., Inflammation 1995 (Osteosarcoma) : Although TNF-alpha suppresses the induced increase in steady-state mRNA levels of u-PA and PAI-1 during maturation of extracellular matrix ( ECM ), the u-PA/PAI-1 ratio is altered in such a way that PA activity associated with the ECM is higher than control cells
Emeis et al., Blood 1995 : Thus, the data suggest that, in rats in vivo, TNF-alpha and IL-1 are not significantly involved in the induction of PAI-1 by endotoxin
van Hinsbergh et al., Blood 1994 : In contrast to TNF-alpha induced PAI-1 production, the transcription and synthesis of urokinase-type plasminogen activator ( u-PA ) was not inhibited by genistein ... A TNF-alpha-mutant ( Trp32Thr86TNF alpha ) that specifically recognizes the 55-kD TNF-receptor, mimicked the effects of TNF alpha on both PAI-1 and u-PA
Campbell et al., Biochim Biophys Acta 1994 (Joint Diseases) : The effects of TNF alpha and TGF-beta on PAI-1 antigen levels were both time- and concentration dependent ; optimum doses being 10-100 pM TNF alpha and 0.4-0.8 nM TGF-beta, with each cytokine exerting its effect on PAI-1 antigen levels within 8 h of addition to culture
Whawell et al., Br J Surg 1994 : Thus TNF may mediate increased PAI-1 release in inflamed peritoneum ... TNF significantly increased the mean ( s.e.m. ) release of PAI-1 by human peritoneal mesothelial cells in vitro at 4 h ( control 1.84 ( 0.17 ) ng/micrograms versus TNF 2.37 ( 0.17 ) ng/micrograms, P < 0.05 ), 6 h ( 2.53 ( 0.09 ) versus 3.88 ( 0.46 ) ng/micrograms, P < 0.05 ), 18 h ( 0.50 ( 0.02 ) versus 1.04 ( 0.11 ) ng/micrograms, P < 0.05 ) and 24 h ( 0.87 ( 0.05 ) versus 1.35 ( 0.11 ) ng/micrograms, P < 0.05 )
Yamamoto et al., Biol Pharm Bull 1993 : In contrast, PAI-1 : Ag release was significantly increased by either IL-1 beta or TNF alpha ; ET-1 significantly reduced the stimulatory effect of the cytokines
Zoellner et al., Thromb Haemost 1993 : IL-1 alpha and TNF alpha increased the synthesis of PAI-2 and PAI-1 by EC in a dose dependent manner
Samad et al., J Clin Invest 1996 : Endotoxin also induced PAI-1 in endothelial cells, while TNF-alpha additionally induced it in smooth muscle cells
Lee et al., Circ Res 1996 : Enzyme linked immunosorbent assay of culture media showed that TNF-alpha ( 10 ng/mL ) increased PAI-1 secretion by 4.2 fold compared with control ( 105.5 +/- 9.6 ) versus 24.9 +/- 1.7 ng/mL, n = 3 ) ... In addition, the induction of PAI-1 by TNF-alpha and plasminogen suggests a negative feedback mechanisms limit both plasmin mediated and MMP mediated matrix degradation
Sitrin et al., J Leukoc Biol 1996 (Leukemia, Myeloid) : Anti-uPA monoclonal antibody ( mAb ) suppressed LPS-driven TNF-alpha secretion by 61.6 +/- 5.9 % ( P < .001 ), and PAI-1 , a uPA inhibitor, suppressed it to 53.1 +/- 8.2 % of the control value ( P < .001 )
Kornelisse et al., J Infect Dis 1996 (Meningococcal Infections...) : Thus, an increased PAI-1 response to TNF-alpha may be associated with fatality, probably because of polymorphism of the PAI-1 gene
Le Magueresse-Battistoni et al., Endocrinology 1997 : TNF alpha action on PAI-1 , like that of TGF alpha demonstrated previously, was masked by a preexposure to phorbol myristate acetate ( a stimulator of protein kinase C ) and strongly reduced by staurosporine ( an inhibitor of the protein kinase C ) ... Together, the present findings suggest that some of the biological effects of TNF alpha on PAI-1 might be secondary to de novo synthesis of EGFR ... Because TNF alpha probably originates from testicular macrophages, such a regulation of PAI-1 by TNF alpha may occur in the context of physiological interactions between the testis and the immune system
Samad et al., Ann N Y Acad Sci 1997 (Aneurysm...) : Since both TNF-alpha and insulin are known to increase in obesity, the elevated levels of PAI-1 observed in the plasma of obese individuals may result from TNF-alpha and/or insulin induction of PAI-1 in the adipose tissue itself
Yamashita et al., Thromb Res 1997 : Although a recent study insists that inhibition of tumor necrosis factor alpha (TNF alpha) does not reduce the induction of PAI-1 by endotoxin in rats, we imagine that TNF alpha is involved in the induction of PAI-1 by endotoxin, because endotoxin treatment induces TNF alpha and administration of TNF alpha induces PAI-1 both in vitro and in vivo ... These results suggest that TNF alpha is responsible , at least in part, for the induction of PAI-1 by endotoxin in vivo
Estellés et al., Thromb Haemost 1998 (Pre-Eclampsia...) : The elevated TNFalpha in the placenta may induce PAI-1 and TF, and thus promote the thrombotic alterations associated with preeclampsia
Soeda et al., Biochim Biophys Acta 1998 : The increase in PAI-1 release by this mechanism was suppressed by a cyclooxygenase inhibitor, aspirin, whereas the inhibitor did not affect TNF-alpha induced increase in PAI-1 release