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SEA — TNF

Text-mined interactions from Literome

Kum et al., J Infect Dis 2001 : MAb5 blocked SEA binding to human monocytes, cross neutralized SEA induced T cell mitogenesis and TNF-alpha secretion in human peripheral blood mononuclear cells, and prevented lethality in mice
Andersson et al., Immunology 1992 : FK506 or CsA inhibited SEA induced tumour necrosis factor-alpha (TNF-alpha) production both in monocytes ( P less than 0.01 ) and in lymphocytes ( P less than 0.001 ), at a drug concentration of 1-25 ng/ml for FK506 and 100-500 ng/ml for CsA
Wilson et al., Infect Immun 2008 (Hepatomegaly...) : Tumor necrosis factor alpha levels in response to stimulation with SEA were high, and a negative association between presentation with hepatomegaly and the levels of the regulatory cytokines interleukin-6 and transforming growth factor beta(1) suggests that a possible mechanism for childhood hepatomegaly in areas where both malaria and schistosomiasis are endemic is poor regulation of an inflammatory response to schistosome eggs
Desouza et al., Eur J Pharmacol 2009 : Increased production of TNF-alpha and IL-1 in alveolar macrophages was observed in response to SEA and SEB
Correale et al., J Immunol 2009 (Multiple Sclerosis...) : SEA suppressed the LPS induced DCs production of IL-1beta, IL-6, IL-12, and TNF-alpha and enhanced TGF-beta as well as IL-10 production
Ferreira et al., Mem Inst Oswaldo Cruz 2012 (Chronic Disease...) : We demonstrate that stimulation with SEA induced prominent lymphocyte proliferation and high levels of tumour necrosis factor (TNF)-a , interleukin (IL)-4 and IL-10 secretion in both OST and non infected individuals ( NI )
Dohlsten et al., Immunology 1993 : Reverse transcriptase-polymerase chain reaction ( RT-PCR ) analysis demonstrated that SEA induced TNF-alpha and IFN-gamma mRNA reached maximal levels 1 hr after SEA administration in TGV beta 3 mice, whereas peak serum levels of TNF-alpha and IFN-gamma proteins were recorded after 2 hr. Comparison of the mRNA levels of a panel of cytokines in the TGV beta 3 and non-TG mice revealed that almost similar amounts of interleukin-1 (IL-1) were induced in both strains, whereas IL-4 was only detected at significant levels in the TGV beta 3 mouse
Chapes et al., J Leukoc Biol 1994 : However, only SEA induced increased TNF mRNA levels
Pontzer et al., Biochem Biophys Res Commun 1993 : Further, polyclonal antibody to SEA ( 121-149 ) inhibited induction of TNF alpha by both SEA and toxic shock syndrome toxin one
Hobeika et al., Biochem Biophys Res Commun 1996 : A synthetic peptide of this region, SEA ( 121-149 ), blocks SEA binding to class II MHC molecules and induces interleukin-1 and tumor necrosis factor production in monocytes
Shankar et al., Cell Immunol 1996 : The results of this study indicate that SEA induces the secretion of IL-1 alpha and TNF alpha by epidermal cells, that these cytokines induce LC depletion from epidermis, and that antibodies specific for these agents inhibit the depletion of LC by SEA
Darville et al., Infect Immun 1997 : Pretreatment of SEA with 0.1 mg of IVIG per ml resulted in a slight decrease of SEA induced TNF-alpha secretion by MO