◀ Back to TNF

REN — TNF

Text-mined interactions from Literome

Wang et al., J Cell Physiol 2000 : These data indicate that the induction of AEC apoptosis by TNF-alpha requires a functional renin/angiotensin system (RAS) in the target cell
Todorov et al., Am J Physiol Regul Integr Comp Physiol 2002 : Tumor necrosis factor-alpha inhibits renin gene expression ... Therefore we have tested the effect of TNF-alpha on renin transcription in As4.1 cells, which represent transformed mouse JG cells, and in native mouse JG cells in culture ... TNF-alpha inhibited renin gene expression via an inhibition of the transcriptional activity, targeting the proximal 4.1 kb of the renin promoter in As4.1 cells ... TNF-alpha also attenuated forskolin stimulated renin gene expression in primary cultures of mouse JG cells ... Our data suggest that TNF-alpha inhibits renin gene transcription at the cellular level and thus may act as a modulator of renin synthesis in ( physio ) pathological situations
Todorov et al., J Biol Chem 2004 : Tumor necrosis factor-alpha activates NFkappaB to inhibit renin transcription by targeting cAMP-responsive element ... Our results strongly suggest that NFkappaB mediates the effect of TNFalpha on renin transcription targeting a CRE in the mouse renin promoter
Fowler et al., Am J Physiol Endocrinol Metab 2009 (Obesity) : In contrast, forskolin and TNFalpha each increased renin protein secretion 12- and sevenfold, respectively
Ino et al., Arterioscler Thromb Vasc Biol 2009 (Disease Models, Animal) : Interestingly, TNF-alpha induced renin activity and angiotensin II production in HUVECs were also blunted by aliskiren
Antonipillai et al., Endocrinology 1990 : Tumor necrosis factor and interleukin-1 may regulate renin secretion ... We have studied the direct effects of recombinant and purified TNF and IL-1 on renin secretion using both static incubations and perifusions of rat renal cortical slices ... TNF similarly induced renin release [ control, 97 +/- 6 % ; TNF ( 10 U/ml ), 151 +/- 13 % ; P less than 0.005 ] ... TNF and recombinant human IL-1 beta ( rhIL-i beta ) also blocked the inhibitory actions of angiotensin-II ( AII ) on renin release [ control, 100 +/- 3 % ; AII ( 2 X 10 ( -7 ) M ), 80 +/- 5 % ; AII plus TNF ( 20 U/ml ), 102 +/- 7 % ; AII plus rhIL beta ( 10 U/ml ), 106 +/- 6 % ; both P less than 0.02 vs. AII ] ... The stimulatory effects of TNF and IL-1 on renin were reversible ... These results suggest that IL-1 and TNF are renin secretagogues and can also block the inhibitory actions of AII on renin ... Since the effect of TNF and IL-1 on renin can be blocked by a ( CO ) inhibitor, the studies indicate a role of prostaglandins in their action
Hermus et al., J Steroid Biochem Mol Biol 1990 : IL1 and TNF inhibit aldosterone production by rat adrenocortical cells in vitro and stimulate renin release by rat renal cortical cells
Jikihara et al., J Clin Endocrinol Metab 1995 : Tumor necrosis factor-alpha and interleukin-1 beta inhibit the synthesis and release of renin from human decidual cells
Jikihara et al., Biol Reprod 1996 : In addition to inhibiting basal renin expression, IFN gamma potentiated the inhibitory effect of tumor necrosis factor alpha (TNF alpha) on renin expression