Paul et al., J Biol Chem 2000
(MAP Kinase Signaling System) :
Acute phorbol 12-myristate 13-acetate pretreatment also inhibited TNFalpha stimulated SAP kinase activity, while chronic pretreatment reversed the effects of UTP
Chung et al., Mol Ther 2003
(Arthritis, Rheumatoid...) :
We found that the histone deacetylase (HDAC) inhibitors ( phenylbutyrate and trichostatin A ) causing histone hyperacetylation to modulate multiple gene expression not only induced the expression of p21 ( Cip1 ) and p16(INK4) in synovial cells but also inhibited the expression of tumor necrosis factor-alpha in affected tissues in adjuvant arthritis, an animal model of RA
Tong et al., Biochem Biophys Res Commun 2004
(Colonic Neoplasms) :
The HDAC inhibitors butyrate and TSA blocked the TNF-alpha activation of Cox-2 protein and mRNA synthesis, and dramatically suppressed Cox-2 activity in HT-29 cells