◀ Back to TNF

MMP3 — TNF

Text-mined interactions from Literome

Gallery et al., Microvasc Res 1999 (Pre-Eclampsia...) : Neither tumor necrosis factor-alpha nor transforming growth factor-beta, both thought to have significant roles in the control of placentation, affected MMP secretion
Meisser et al., Mol Hum Reprod 1999 : The aim of this study was to determine the effects of tumour necrosis factor alpha (TNF) , interleukin-1 alpha (IL-1alpha), macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases ( MMP ) , human chorionic gonadotrophin ( HCG ) and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro
Watari et al., Am J Pathol 1999 : TNF-alpha induced cathepsin S, MMP-1 , -3, and -9 mRNA expression in a dose dependent manner : the maximal effect was observed at a concentration of 10 ng/ml, with appreciable increases observed at concentrations of 0.1 to 1.0 ng/ml
Conant et al., Ann Neurol 1999 (AIDS Dementia Complex) : We also examined the possibility that such MMPs could be produced by brain derived cells, and that MMP production by these cells might be increased by tumor necrosis factor-alpha , an inflammatory cytokine that is produced by HIV infected monocytes/microglia and is elevated in HIVD
Nakada-Tsukui et al., J Leukoc Biol 1999 : Although only hydroxamate matrix metalloproteinase ( MMP ) inhibitors inhibited the basal processing and release of TNF-alpha , the PMA induced processing and release of TNF-alpha were inhibited not only by MMP inhibitors but also by 1,10-phenanthroline, 3,4-dichloroisocoumarin ( 3,4-DCI ), iodoacetamide, and Nalpha-p-tosyl-L-phenylalanine chloromethyl ketone ( TPCK )
Haro et al., J Clin Invest 2000 (Bone Resorption...) : The generation of soluble TNF-alpha was essential for the induction of MMP-3 in disc cocultures, which in turn is required for the generation of a macrophage chemoattractant and subsequent macrophage infiltration
Chambaut-Guérin et al., J Neurochem 2000 (Neuroblastoma) : In contrast, MMP-9 was inducible by RA, TNFalpha , or PMA
Siwik et al., Circ Res 2000 : IL-1beta and TNF-alpha each increased total matrix metalloproteinase ( MMP ) activity as measured by in-gel zymography, causing specific increases in the bands corresponding to MMP-13, MMP-2, and MMP-9
Han et al., J Cell Sci 2001 : To investigate this observation at the cellular and molecular levels, we examined TNF-(alpha) mediated activation of pro-MMP-2, induction of MT1-MMP , and the intracellular signaling pathways that regulate the proteinase in isolated human dermal fibroblasts
Schweyer et al., Virchows Arch 2000 (Gout) : These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes, MMP-2 and MMP-9, suggesting that TNF-alpha may induce MMP production followed by matrix degradation within foreign body granulomas
Sakai et al., J Bone Miner Res 2001 : Furthermore, the inhibitors completely prevented the TNF-alpha dependent induction of MMP-1, MMP-3 , ICAM-1, and COX-2 mRNAs
Baram et al., J Immunol 2001 : MMP-9 release was first detected at 6 h and peaked at 22 h of incubation with activated T cell membranes, while TNF-alpha release peaked after only 6 h. Anti-TNF-alpha mAb inhibited the T cell membrane induced MMP-9 release, indicating a possible autocrine regulation of MMP release by mast cell TNF-alpha
Miyajima et al., Microb Pathog 2001 (Corneal Ulcer...) : Effects of pseudomonal virulence factors [ elastase, alkaline protease, exotoxin A and lipopolysaccharide (LPS) ], tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta on MMP induction and activation were further examined in vitro in rabbit corneal fibroblasts ( RCF ) and human fibrosarcoma ( HT1080 ) cells using reverse transcriptase-polymerase chain reaction ( RT-PCR ), zymography and immunoblotting
Majka et al., Invest Ophthalmol Vis Sci 2002 (Retinal Neovascularization) : Isolated RMVECs did not significantly increase MMP production directly in response to a hypoxic stimulus, but required the presence of exogenous TNFalpha ... TNFalpha increased the expression of MT1-MMP , MMP-3, and MMP-9 in these cells
Nishikawa et al., J Periodontal Res 2002 : This study used reverse transcriptase-PCR to investigate the effects of TNFalpha on matrix metalloproteinase ( MMP ) mRNA expression in human periodontal ligament fibroblasts ... TNFalpha increased MMP-1, MMP-3 and MMP-13 mRNA levels in both a time dependent ( 0-24 h ) and a dose dependent ( 0.1-10 ng/ml ) manner ... Because elevation of COX-2 mRNA levels enhances the production of prostaglandins, we therefore investigated whether endogenous prostaglandins are involved in the MMP mRNA expression that is enhanced by TNFalpha
Domeij et al., Eur J Oral Sci 2002 (MAP Kinase Signaling System) : The results showed that gingival fibroblasts constitutively produce MMP-1 and MMP-3 , and that the cytokines IL-1beta, TNFalpha and EGF increase both MMP-1 and MMP-3 production in gingival fibroblasts ... In addition, MMP-1 and MMP-3 production, induced by IL-1beta, TNFalpha or EGF, was strongly reduced by the presence of the glucocorticoid dexamethasone ... Our findings demonstrate that the cytokines IL-1beta, TNFalpha and EGF, respectively, enhance both MMP-1 and MMP-3 production in human gingival fibroblasts, and that the signal pathways COX-2, MAP-kinases and tyrosine kinases are partly involved in the production of MMPs
Alexander et al., Invest Ophthalmol Vis Sci 2003 (MAP Kinase Signaling System) : The components of this MAP kinase pathway in the TM are dramatically affected by TNFalpha and inhibition of Erk 's phosphorylation blocks the changes in MMP and TIMP expression
Hirata et al., Biol Reprod 2003 : Membrane type-1 MMP mRNA expression in the stromal cells was augmented by tumor necrosis factor alpha (TNFalpha) , IL-6, HGF, and 12-O-tetradecanoylphorbol 13-acetate
Lee et al., J Allergy Clin Immunol 2003 (Asthma...) : These results suggest that MMP inhibitors regulate inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing IL-1beta, IL-4, and TNF-alpha expression
Bamba et al., J Gastroenterol 2003 : In human colonic SEMFs, MMP-3 secretion and MMP-3 mRNA expression were induced by IL-17, IL-1beta, and TNF-alpha ... In human colonic SEMFs, MMP-3 secretion and MMP-3 mRNA expression were induced by IL-17, IL-1beta, and TNF-alpha ... A c-Jun/activating protein-1 (AP-1) inhibitor, curcumin, reduced the IL-17-, IL-1beta-, and TNF-alpha induced MMP-3 mRNA expression, and mitogen activated protein ( MAP ) kinase inhibitors ( U0126, PD098059, and SB203580 ) also blocked MMP-3 secretion ... Colonic SEMFs actively secreted MMP-3 in response to IL-17, IL-1beta, and TNF-alpha
Wang et al., Cardiovasc Res 2003 : TNF-alpha mediates the stretch induced MMP genes expression, at least in part, through the JNK pathway
Hui et al., Arthritis Rheum 2003 (Osteoarthritis, Knee) : The in vivo data clearly indicated that OSM + TNFalpha overexpression increased MMP levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 ) ... Specifically, OSM + TNFalpha induced marked synovial hyperplasia, inflammation, and cartilage and bone destruction with a concomitant increase in MMP expression in both cartilage and synovium and decreased TIMP-1 expression in the articular cartilage
Moon et al., J Cell Physiol 2004 : Finally, the transient transfection of HASMC with dominant negative Ras ( RasN17 ) suppressed TNF-alpha induced ERK activity, MMP-9 production, and promoter activity
Fuchs et al., Osteoarthritis Cartilage 2004 : TNFalpha , IL-1alpha, and IL-1beta led to marked increases in MMP-1 and MMP-3 release ( up to 4.2-fold and 547-fold, respectively ) by synovial fibroblasts, whereas secretion of MMP-13 was induced by concomitant administration of TNFalpha and IL-1beta
Behera et al., Infect Immun 2004 (MAP Kinase Signaling System) : Inhibition of tumor necrosis factor alpha (TNF-alpha) significantly reduced MMP-1 but not MMP-3 expression from B. burgdorferi infected cells ; inhibition of interleukin-1beta (IL-1beta) had no effect
Meli et al., J Neuroimmunol 2004 (Disease Models, Animal...) : We investigated the pharmacokinetics and the effect of TNF484 , a water-soluble hydroxamate based inhibitor of MMP and TACE, on disease parameters and brain damage in a neonatal rat model of pneumococcal meningitis
Churg et al., Am J Respir Crit Care Med 2004 (Pulmonary Emphysema) : TNF-alpha causes increased MMP production, but some increased MMP activity is present even in TNFRKO mice
Dayer et al., Reumatismo 2004 (Arthritis, Rheumatoid) : IL-1 and TNF-alpha are potent inducers of matrix metalloproteinases ( MMP ) , eicosanoids, nitric oxide oxydase ( iNOS ), receptor activator of NF-kB ligand ( RANKL ), products involved in the destruction of the extracellular matrix, the cartilage and in bone resorption
Kobayashi et al., Arthritis Rheum 2005 (Osteoarthritis, Knee) : Independent analyses of gene expression in cultured cartilage from 9 other OA patients revealed that IL-1 or TNFalpha blockade, either alone and/or in combination, frequently down-regulated MMP-1, MMP-3 , and MMP-13 expression ... Independent analyses of gene expression in cultured cartilage from 9 other OA patients revealed that IL-1 or TNFalpha blockade, either alone and/or in combination, frequently down-regulated MMP-1, MMP-3 , and MMP-13 expression
Bruce et al., Toxicol Appl Pharmacol 2005 (Asthma...) : Tumor necrosis factor alpha (TNFalpha) has been shown to be an important cytokine in the pathogenesis of allergic airway inflammatory responses, and its release can be inhibited by MMP inhibitors
Liacini et al., Arthritis Res Ther 2005 : MMP-3 and MMP-13 gene expression induced by IL-1beta, TNF-alpha and IL-17 was downregulated by mithramycin in human chondrosarcoma SW1353 cells and in primary human and bovine femoral head chondrocytes
Shimizu et al., Mediators Inflamm 2005 (Rhinitis, Allergic, Perennial) : We evaluated whether tranilast ( TR ) could inhibit MMP production from nasal fibroblasts in response to tumor necrosis factor-alpha (TNF-alpha) stimulation in vitro
Krueger et al., J Biol Chem 2006 : In vitro, MMP-1 is up-regulated by interleukin-1beta and tumor necrosis factor-alpha , but these regulatory mechanisms are not operating in H. pylori infection as shown by inhibitory antibodies
Sondergaard et al., Osteoarthritis Cartilage 2006 : TNF-alpha and OSM induced a pronounced increase in matrix metalloproteinase ( MMP ) activity, which was strongly inhibited by calcitonin
Hosseini et al., Invest Ophthalmol Vis Sci 2006 : IL-1 and TNF induction of matrix metalloproteinase-3 by c-Jun N-terminal kinase in trabecular meshwork ... The involvement of JNK activity in the TNFalpha and IL-1alpha induction of MMP-3 expression was then evaluated ... JNK activity is necessary for the induction of MMP-3 and MMP-9 by TNFalpha , IL-1alpha, or IL-1beta in TM cells
Morita et al., Biochem Biophys Res Commun 2006 (Arthritis, Rheumatoid) : Mu-calpain is involved in the regulation of TNF-alpha induced matrix metalloproteinase-3 release in a rheumatoid synovial cell line ... Tumor necrosis factor ( TNF-alpha ) stimulation induced increased expression of mu-calpain, m-calpain, and MMP-3 in these cells, as well as the release of calpain and MMP-3 into the culture medium ... Down-regulation of mu- but not m-calpain by small interfering RNAs abolished TNF-alpha induced MMP-3 release from the synovial cells
Roy et al., Antioxid Redox Signal 2006 (Inflammation) : Pretreatment of HMECs for 2 days with BE potently prevented TNFalpha induced expression and activity of MMP-3, MMP-10 , and MMP-12
Chung et al., Curr Drug Targets 2006 (Pulmonary Disease, Chronic Obstructive) : TNFalpha and IL-1beta stimulate macrophages to produce matrix metalloproteinase-9 [ MMP-9 ], and bronchial epithelial cells to produce extracellular matrix glycoproteins
Braundmeier et al., Am J Reprod Immunol 2006 (Endometriosis) : TNF-alpha stimulated MMP-1 and -3 protein secretion in a time dependent manner and stimulated MMP-1, -2 and -3 mRNA levels in a time dependent manner ( P < 0.05 )
Fushimi et al., J Cell Biochem 2007 (MAP Kinase Signaling System) : In response to TNF-alpha , MMP-1 is induced and actively released from HCS-2/8 cells
Matsumoto et al., Scand J Gastroenterol 2006 (Disease Models, Animal...) : MMP-3 inhibition ameliorates intestinal damage without apparently affecting either TNF-alpha or TACE production and the dose-response curve suggests that the beneficial effect of the so-called TACE inhibitor is actually mainly mediated via MMP-3 inhibition rather than TNF-alpha inhibition
Lin et al., Nan Fang Yi Ke Da Xue Xue Bao 2006 : To investigate the regulatory effects of fenofibrate on TNF-alpha induced CD40 expression and matrix metalloproteinase ( MMP ) activity in human vascular endothelial cells ( HUVECs )
Inatomi et al., Pancreas 2007 : In human pancreatic myofibroblasts, MMP-3 secretion and mRNA expression were induced by interleukin (IL)-17, IL-1beta, and tumor necrosis factor (TNF) -alpha, respectively ... In human pancreatic myofibroblasts, MMP-3 secretion and mRNA expression were induced by interleukin (IL)-17, IL-1beta, and tumor necrosis factor (TNF) -alpha, respectively ... Pancreatic periacinar myofibroblasts actively secrete MMP-3 in response to IL-17, IL-1beta, and TNF-alpha
Kunisch et al., Ann Rheum Dis 2007 (Arthritis, Rheumatoid...) : Reduction of proliferation and induction of IL6, IL8 and MMP-1 were solely mediated by TNF-R1, whereas PGE ( 2 ) and MMP-3 secretion was mediated by both TNF-Rs
Zeni et al., Am J Physiol Cell Physiol 2007 : Moreover, MMP activity in PCPEC supernatants was significantly increased by TNF-alpha , presumably due to a diminished expression of TIMP-3 that was similarly observed
Cheng et al., Int J Cancer 2007 (Glioma) : Interferon-gamma regulation of TNFalpha induced matrix metalloproteinase 3 expression and migration of human glioma T98G cells
Kelley et al., Invest Ophthalmol Vis Sci 2007 : TNF-alpha , IL-1alpha, and IL-1beta each individually increased MMP-3 levels, whereas TNF-alpha in combination with IL-1alpha or IL-1beta produced highly synergistic increases
Yagi et al., J Gastroenterol 2007 (Colitis) : A similar augmentation was also observed in tumor necrosis factor (TNF)-alpha induced cytokine and MMP secretion
Oner et al., J Clin Endocrinol Metab 2008 (Chorioamnionitis...) : We hypothesized that IL-1beta and TNF-alpha may induce matrix metalloproteinase (MMP)-1 and MMP-3 activity to promote PTD by degrading decidual and fetal membranes and cervical extracellular matrix ... Our objective was to evaluate : 1 ) MMP-1 and MMP-3 expression in decidual sections from uncomplicated term, idiopathic preterm, and CAM complicated deliveries, and 2 ) the separate and interactive effects of IL-1beta, TNF-alpha , medroxyprogesterone acetate ( MPA ), and a p38 MAPK inhibitor ( SB203580 ) on MMP-1 and MMP-3 expression in term decidual cells (DCs) ... Compared with basal outputs by DCs incubated with E2, TNF-alpha enhanced MMP-1 and MMP-3 secretion by 14 +/- 3- and 9 +/- 2-fold, respectively, and IL-1beta increased MMP-1 and MMP-3 secretion by 13 +/- 3- and 19 +/- 2-fold, respectively ( P < 0.05 )
Gamo et al., J Exp Zool A Ecol Genet Physiol 2007 : The effects of TNF-alpha on proliferation and MMP production of RES have been shown for the first time
Séguin et al., Spine (Phila Pa 1976) 2008 : The effect of TNF-alpha on membrane type (MT)1-MMP , an activator of MMP-2, was also assessed
Unoki et al., Int J Obes Relat Metab Disord 2008 (Disease Models, Animal...) : Adipocytes accumulated in the visceral area change their function to induce tumor necrosis factor-alpha (TNF-alpha) secretion with concomitant matrix metalloproteinase (MMP)-3 induction in mice
Kawamura et al., Dig Dis Sci 2009 : Trichostatin A, a histone-deacetylase inhibitor, reduced IL-1 beta induced MMP-1 and MMP-3 mRNA expression, and suppressed TNF-alpha induced MMP-3 mRNA expression
Tenenbaum et al., Brain Res 2008 : Infection with S. suis leads to an inflammatory response exemplified by the induction of tumor necrosis factor (TNF) alpha and matrix metalloproteinase (MMP)-3 gene activation , which correlated with phosphorylation of extracellular signal regulated kinases ( ERKs )
Rogliani et al., Respir Med 2008 (Pulmonary Emphysema...) : In contrast, fibroblasts in areas of parenchymal destruction of emphysema/UIP expressed MMP-2, MMP-9 , MMP-7 and MT1-MMP at variable but significantly higher levels when compared to emphysema subjects, in the presence of similar levels of TIMP-1, TIMP-2 and TNF-alpha
Müller et al., Cytokine 2008 : TNF-alpha suppressed collagen type II and aggrecan, but increased MMP and cytokine expression in chondrocytes compared to the non stimulated controls
Asano et al., Int J Chron Obstruct Pulmon Dis 2008 : We evaluated whether tiotropium bromide hydrate ( TBH ), a M3 muscarinic receptor antagonist, could inhibit MMP production from lung fibroblasts ( LFs ) in response to tumor necrosis factor (TNF)-alpha stimulation
Millward-Sadler et al., Arthritis Res Ther 2009 (Intervertebral Disc Degeneration) : Quantitative real-time polymerase chain reaction was used to assess the effect of TNF-alpha or IL-beta stimulation on the expression of matrix metalloproteinase (MMP)-3 , -9 and -13, TNF-alpha, TNF receptor 1 (TNF-R1), TNF receptor 2 (TNF-R2), IL-1alpha, IL-1beta, IL-1 receptor 1 (IL-1R1) and IL-1 receptor antagonist (IL-1Ra) ... TNF-alpha does not induce MMP expression to the same degree as stimulation by IL-1beta, but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2
Voigt et al., Arthritis Res Ther 2009 : TNFalpha increased matrix metalloproteinase (MMP)-3 and a disintegrin and metalloproteinase with thrombospondin motifs ( ADAMTS)-4 mRNA expression, whereas collagen type I was decreased, and aggrecan, collagen type II as well as MMP-1, -2, -13 and ADAMTS-5 were variably affected
Steenport et al., J Immunol 2009 (Chronic Disease...) : Exposure of macrophages to MMP-1 and MMP-3 triggered the rapid release of TNF-alpha , which was blocked by MMP inhibitors
Awad et al., Am J Physiol Cell Physiol 2010 (Cardiomyopathies...) : We identified phosphatidylinositol 3-kinase (PI3K)gamma as a key factor in TNF mediated events since TNF induced superoxide production, MMP expression, and activity were significantly suppressed in cardiomyocytes and cardiofibroblasts deficient in PI3Kgamma
Murray et al., J Mol Cell Cardiol 2010 : While we have previously shown a role for cardiac mast cells in mediating increases in myocardial TNF-alpha, however, matrix metalloproteinase ( MMP ) activation of TNF-alpha may also be contributory
Lee et al., J Immunol 2010 : The inhibition of MMP-3 , -8, or -9 significantly reduced NO and reactive oxygen species levels and suppressed the expression of TNF-alpha and IL-1beta ... Notably, MMP-8 inhibitor suppressed TNF-alpha production more efficaciously than MMP-3 or MMP-9 inhibitors
Park et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2011 : MMP inhibitors, such as doxycycline, minocycline, and batimastat, significantly reduced the cerebral infarct size, and the expressions of monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-a (TNF-a) , and indoleamine 2,3-dioxygenase (IDO)
Christianson et al., Neuroscience 2012 (Disease Models, Animal...) : Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a tumor necrosis factor dependent mechanism
Clérigues et al., Biochem Pharmacol 2012 (Osteitis...) : HO-1 induction significantly reduced the expression of matrix metalloproteinase (MMP)-1, MMP-2 and MMP-3 , and the production of pro-inflammatory cytokines such as tumor necrosis factor-a and IL-6 whereas IL-10 levels increased
Kular et al., Journal of neuroinflammation 2012 (Disease Models, Animal...) : In vitro, results based on cultured DRG neurons showed that siRNA mediated inhibition of NOV enhanced IL-1ß- and TNF-a induced MMP-2, MMP-9 and CCL2 expression whereas NOV addition inhibited TNF-a induced MMP-9 expression through ß1 integrin engagement
Yamaguchi et al., Immunopharmacol Immunotoxicol 2012 (Arthritis, Rheumatoid...) : E ( 2 ) possessed a suppressive effect for apoptosis and a promotive effect for tumor necrosis factor (TNF)-a induced matrix metalloproteinase (MMP)-3 production on the synovial fibroblasts ... The present data suggest that E ( 2 ) has adverse effects on the pathogenesis of RA as a result of unregulated cell death, increased TNF-a induced MMP-3 production, and CCL13 overproduction, subsequently resulting in the disease progression of RA
Moon et al., Osteoarthritis Cartilage 2013 (Osteoarthritis, Knee) : Resveratrol dose-dependently inhibited TNF-a induced cyclooxygenase-2 (COX-2), MMP-1, MMP-3 , MMP-13 and PGE ( 2 ) production in human chondrocytes
Tian et al., Rheumatol Int 2013 : The present study was designed to investigate the effects of resveratrol on TNF-a induced inflammatory cytokines production of IL-1ß and MMP3 in Rheumatoid arthritis ( RA ) Fibroblast-like synoviocytes ( FLS ) and further to explore the role of PI3K/Akt signaling pathway by which resveratrol modulates those cytokines production ... Activation of PI3K/Akt signaling pathway exists in TNF-a induced production of IL-1ß and MMP3 on RA FLS, which is hampered by PI3K inhibitor LY294002 ... Resveratrol attenuates TNF-a induced production of IL-1ß and MMP-3 via inhibition of PI3K-Akt signaling pathway in RA FLS, suggesting that resveratrol plays an anti-inflammatory role and might have beneficial effects in preventing and treating RA
Yamada et al., Biochem Pharmacol 2013 : The expression of MMP-1, MMP-3 , and MMP-9 increased in the presence of TNF-a , and the addition of infliximab reversed the increase ... The expression of MMP-1, MMP-3 , and MMP-9 increased in the presence of TNF-a , and the addition of infliximab reversed the increase ... Furthermore, infliximab effectively attenuated the TNF-a induced increases in MMP expression in cells that make up the BAB
Cornelius et al., J Invest Dermatol 1995 (Neovascularization, Pathologic) : Northern hybridization assays showed pretranslational control of PMA-, basic fibroblast growth factor-, and TNF-alpha induced MMP expression
Gearing et al., J Leukoc Biol 1995 : MMP inhibitors prevent the rise in blood levels of TNF after endotoxin administration in rats and are effective in animal models of inflammatory disease such as adjuvant arthritis
Rawdanowicz et al., J Clin Endocrinol Metab 1994 : Both interleukin-1 alpha and tumor necrosis factor-alpha stimulated the secretion of MMP-1, MMP-3 , and MMP-9, but not MMP-2, from the cells in a concentration dependent manner
Ries et al., Blood 1994 (Leukemia, Promyelocytic, Acute) : Thus, MMP-9 secretion may be regulated by TNF-alpha not only in a paracrine but also in an autocrine fashion
Hanemaaijer et al., Biochem J 1993 : On the other hand, MMP-2 and TIMP-2 were not affected or were affected in a variable way by TNF alpha and/or phorbol ester, suggesting a dissimilar regulation of these proteins
Migita et al., Immunology 1996 (Arthritis, Rheumatoid) : In support of this result, TNF-alpha stimulation induced membrane-type matrix metalloproteinase ( MT-MMP ), a newly identified MMP-2-specific activator on synovial fibroblasts ... Cycloheximide analysis demonstrated that protein synthesis may be required for TNF-alpha mediated MT-MMP expression on synovial fibroblasts
Pender et al., J Immunol 1998 : Recombinant TNF-alpha and IL-1beta added directly to mucosal mesenchymal cell lines also caused an increase in MMP production, but only the former was inhibited by the TNFR-IgG
Uitto et al., Am J Pathol 1998 (Gingivitis...) : In these cells, MMP-13 expression at the mRNA and protein level was potently enhanced ( up to sixfold ) by tumor necrosis factor-alpha , transforming growth factor-beta(1), and transforming growth factor-alpha and by keratinocyte growth factor in the presence of heparin
Mentzel et al., Clin Exp Rheumatol 1998 (Arthritis, Reactive) : TNF-alpha increased the total MMP activity released
Knittel et al., J Hepatol 1999 : In general, TNF-alpha stimulated both MMP and TIMP expression of hepatic stellate cells, while TGF-beta1 induced TIMP expression only
Wassenaar et al., Clin Exp Immunol 1999 : This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when MMP production was up-regulated by IL-1beta and TNF-alpha or down-regulated by IFN-gamma