◀ Back to TNF

GSTM3 — TNF

Text-mined interactions from Literome

Mangalam et al., Int Immunopharmacol 2001 : We studied the effect of GSTM on spontaneous and LPS stimulated TNF-alpha production by human peripheral blood mononuclear cells ( PBMCs ) of normal volunteers ... GSTM stimulated spontaneous TNF-alpha production and inhibited LPS stimulated TNF-alpha production in 16 of 24 ( 75 % ) individuals of LPS-responsive group and one of six individuals ( 17 % ) of LPS-non-responsive group ... We conclude that there is a heterogeneity among normal population for TNF-alpha production in response to LPS, and GSTM inhibits LPS stimulated TNF-alpha production, primarily in LPS responders
Kumar Mangalam et al., Cell Immunol 2002 : We have previously shown that GSTM , an anti-rheumatic drug inhibits LPS stimulated TNF-alpha production by normal PBMCs ... Thus, we for the first time report that GSTM inhibits LPS stimulated TNF-alpha production through ceramide pathway and anti-inflammatory activity of GSTM in treatment of RA may depend on its ability to inhibit NF-kappaB activation and TNF-alpha production
Yadav et al., Int J Immunopharmacol 1997 (Arthritis, Rheumatoid) : GSTM and MTX augmented spontaneous TNF alpha production in normal individuals and patients with RA but did not influence LPS stimulated TNF alpha production ... These data indicate that GSTM can inhibit TNF alpha production when the PBMC are preactivated by LPS